Project Grant R56AR082995

Award Date 9/19/23
Completion Date 8/31/24
Dollars Obligated $226K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02139, USA
Similar Awards
This $680,325 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the fundamental mechanisms of collagen proteostasis and the development of new therapeutic approaches for collagen-related diseases, known as the "collagenopathies." The research, to be conducted by the Massachusetts Institute of Technology (MIT) over a...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the use of collagenase to target collagen architecture in fibrotic skeletal muscle. The total funding amount is $123,424.00, with an award date of September 26, 2024 and ultimate completion date of April 30, 2026. The research will utilize the D2.MDX mouse model of...
The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $163,514 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. in Boston, MA. The grant, awarded on July 1, 2024, supports research to biochemically define a new G protein-coupled receptor (GPCR) signaling pathway with relevance to chemokine signaling and T cell function. The principal investigator, with mentorship...
The Massachusetts Institute of Technology (MIT) was awarded a $1,551,000 Project Grant from the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420). The grant will support MIT's development of a strain-programmable bioadhesive patch for accelerated healing of diabetic ulcers from July 1, 2021 to June 30, 2025. The Military Medical Research and Development program aims to transform military and public health through innovative medical...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop specialized cryo-electron microscopy (cryo-EM) techniques to study the structures of mitochondrial complexes implicated in muscular myopathies. The $444,109 award to the Scripps Research Institute in La Jolla, CA will support the creation of methods to directly visualize endogenous...
This $2,862,000 project grant from the National Institutes of Health's National Institute of General Medical Sciences will support research into the molecular regulation of mechanotransduction over a three-year period ending in August 2025. The grant recipient, the Massachusetts Institute of Technology, will investigate how focal adhesions form and mature to transmit mechanical forces across the plasma membrane through integrin receptors. The researchers will take advantage of a novel...
This $686,029 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the role of collagen VII in extracellular matrix protein secretion. The research aims to investigate protein secretion defects identified in recessive dystrophic epidermolysis bullosa (RDEB) fibroblasts and determine the mechanism of action of anti-viral drugs in...
The National Institute of General Medical Sciences (NIGMS) awarded a $358,012 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the Massachusetts Institute of Technology (MIT) to support research on developing a new stereochemical editing strategy for creating quaternary stereocenters. The objective is to establish a dual asymmetric photoredox/nickel catalysis system and explore the use of chiral counteranions to precisely control the stereochemistry of these complex...
The Massachusetts Institute of Technology (MIT) was awarded a $800,000 Project Grant from the National Science Foundation (NSF) to conduct collaborative research titled "Learning How Mucus Shapes and Maintains Microbiomes" from September 1, 2021 through August 31, 2026. Under the award, MIT researchers will work to advance understanding of the role that mucus plays in shaping and maintaining microbiomes. The research is funded through the NSF's Biological Sciences program (CFDA...
The National Science Foundation awarded a $760,000 project grant to the Massachusetts Institute of Technology from February 1, 2021 through January 31, 2024. The grant is part of NSF's Biological Sciences program (CFDA 47.074) to promote advancement in the biological sciences. Under the award, MIT researchers will investigate protein regulators of three-dimensional genome architecture, dynamics, mechanism and function. Specifically, the grant will fund research into how proteins control the...

The Massachusetts Institute of Technology (MIT) has been awarded a $225,623 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will support research to elucidate the critical mechanisms of intracellular collagen folding and quality control, with the goal of identifying new therapeutic targets for treating collagen-related diseases, known as collagenopathies. The research will leverage advanced cell culture models to assess the potential of proteostasis network-targeted interventions for addressing the upstream causes of collagenopathies, which currently lack effective disease-modifying therapies. The award has a project period from September 19, 2023 to August 31, 2024.

Generated 8/13/24, 7:12 AM