Project Grant R56AR060788

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $611,728 to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley) to study the molecular mechanisms by which the transcription factor Dorsal controls gene expression dynamics during embryonic development in the fruit fly Drosophila melanogaster. The key objectives...

The University of Washington will receive $1,876,269 under a three-year Project Grant award from the National Institutes of Health National Institute of Child Health and Human Development (NICHD) Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will support research using Drosophila melanogaster to investigate motor control and premotor neural circuits in the spinal cord. Researchers will develop a behavioral task for flies to generate specific amounts of...

This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $201,960 to the University of Vermont & State Agricultural College to develop a novel zebrafish model system for studying the functional impact of different myosin-binding protein C (MyBP-C) isoforms on muscle contractility. The research aims to generate "designer"...

This is a Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $422,173 award will support research at the University of Massachusetts Boston to investigate cellular signaling networks that control organ growth and tissue patterning during development. The research will focus on three key signaling pathways: the RTK/ERK pathway, Hippo signaling, and the Minibrain/Dyrk1a kinase network....

This $157,500 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research at The Ohio State University to investigate how systemic signaling pathways coordinate with local growth and patterning mechanisms during the early development of the Drosophila (fruit fly) wing. The research aims to identify the specific systemic signals, such as insulin signaling,...

This Project Grant award of $257,750 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports the development of a comprehensive cell-type-specific genetic toolkit for the Drosophila visual system. The key products and services to be delivered include: Development of a collection of gene-specific split-GAL4 lines that can selectively target 81% of...

This Project Grant award of $522,714.00, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the mechanisms behind skeletal muscle endurance and stretch activation. The research aims to: Test the hypothesis that stretch activation is an alternative mechanism to maintain force production and contribute to skeletal muscle endurance. This will...

This five-year, $649,659 National Science Foundation Engineering Project Grant will support research at the Massachusetts Institute of Technology to advance fundamental understanding of the tissues that produce voluntary movement in humans and other biological creatures. Specifically, the grant will fund experiments studying how mechanical signaling coordinates assembly, maturation and repair at the neuromuscular interface in both physiological and pathological states. The principal investigator...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms responsible for sarcopenia, the loss of muscle mass and function associated with aging. The $576,893 award to the University of Texas Medical Branch at Galveston will test the hypothesis that post-translational modifications of the myosin protein and its chaperone UNC-45 contribute to the diminished muscle function observed in elderly populations....

This $420,883 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to improve muscle regeneration and restore function following serious traumatic injuries. The University of Missouri System, the prime recipient, will leverage its expertise in microvascular imaging, muscle biology, and biomaterials to investigate the role of fibroadipogenic...