This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into proteostasis, neuroinflammation, and neurodegeneration in frontotemporal dementia (FTD). The $630,496 award, granted on June 1, 2025, aims to better define alterations in proteostasis in FTD glial cells, including microglia and astrocytes, and determine if proteostasis impairment in glia, neurons, or both drives neurodegeneration in FTD. The research is being conducted by the J....
This $4,893,884 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research federal grant program (CFDA 93.866). The University of Florida will lead a collaborative effort to understand the role of central and peripheral immune crosstalk in frontotemporal dementia with progranulin mutations (FTD-GRN), an Alzheimer's disease-related dementia. The University of Florida and sub-awardees the J. David Gladstone...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $528,876 to Emory University to conduct research investigating the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The 5-year project, beginning June 1, 2025, aims to develop new analytical tools that can integrate transcriptome-wide and proteome-wide association studies with genome-wide association data...
This $107,948 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to enhance understanding of the biological signatures that distinguish subgroups of patients with Alzheimer's disease (AD). The key goals are to: Determine if AD subtypes can be identified solely using magnetic resonance imaging (MRI)-derived features through the application of machine learning algorithms. Integrate epigenetic profiles, including small non-coding RNA expression and DNA...
This $1,010,081 federal Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports a multi-year research project by Emory University focused on identifying potential "goldilocks zone" immune modulatory therapies for Alzheimer's disease. The overarching goal is to systematically evaluate the liabilities and benefits of different immune system manipulations in preclinical models of amyloid pathology, with the aim of finding interventions that...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the molecular mechanisms underlying the neurodegenerative function of a subset of microglia (the brain's immune cells) in Alzheimer's disease (AD). The $442,357 award, effective December 15, 2024 through November 30, 2029, supports research by the Research Foundation of the City University of New York's Advanced Science Research Center to investigate how cellular stress signaling,...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This Project Grant award of $515,160 was provided by the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), to The Johns Hopkins University. The award will fund research to examine the association between cell-free DNA (CF-DNA) and microglial activation in Alzheimer's disease (AD). Specifically, the project will (1) analyze the relationship between serum CF-DNA levels and microglial activation, and (2) study functional changes in microglia phagocytosis and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Aperture Therapeutics, Inc. in the amount of $459,525 provides funding to rapidly discover a novel oligonucleotide therapeutic for direct modulation of a genetically validated target involved in pathologic neuroinflammation associated with frontotemporal dementia (FTD) and related dementias. The project leverages Aperture's high-throughput iPSC platform with diverse genetic models of FTD to provide...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...