Project Grant R50HL181976
- The National Science Foundation (NSF) Office of Advanced Cyberinfrastructure awarded a 4-year, $1,000,899 Project Grant to The Leland Stanford Junior University (Stanford University) under the NSF's Computer and Information Science and Engineering (CISE) program (CFDA 47.070). The project aims to develop and publicly release a novel suite of multifidelity simulation tools for modeling vascular biomechanics and mechanobiology in the open-source SimVascular project. Specifically, the grant will...
- This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) project grant award provides $598,884 over 4 years to The Regents of the University of California, doing business as the University of California, Berkeley, to develop a novel suite of simulation tools for modeling vascular biomechanics and mechanobiology as part of the open-source SimVascular software platform (CFDA No. 47.041 Engineering). The project aims to enhance...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $459,838 to support software development and community engagement for the Cardinal open-source software infrastructure. The project aims to deliver a unified platform for simulating all major aspects of cardiac function, addressing a critical gap in comprehensive, open-source cardiac modeling tools. This 2-year project, running from August 2025 to July 2027, will...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $640,562 to Duke University to develop advanced computer models that act as "virtual replicas" of a patient's blood vessels and heart activity. Using data from wearable sensors, the investigators will simulate how blood flows and interacts with vessel walls over time, enabling large-scale in silico testing of medical devices and therapies without...
- This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling. The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $999,745 to Iowa State University to develop a novel multiscale digital twin framework for predicting and controlling blood vessel growth after cardiac injury. The key products and services to be delivered include: A multiscale modeling framework that integrates molecular signaling dynamics, cellular migration, sprouting patterns, and tissue-level growth and...
- This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) supports the development of a new computational model to predict the complex interactions between ventricular assist devices (VADs) and the beating native heart. The goal is to create a "digital twin" of an experimental mock circulatory loop used for testing VAD safety and efficacy. This $195,291 award, effective August 1, 2024 through July 31, 2026, will result in a lumped parameter model that...
- This $200,000 Project Grant award from the National Science Foundation's Computer and Information Science and Engineering (CFDA 47.070) program will fund the development of advanced computational methods to create high-fidelity, fast-running digital twins of patient hearts and cardiovascular medical devices. The project aims to deliver: 1) novel machine learning algorithms for accurate digital twin geometry reconstruction from 3D medical images, 2) an efficient inverse method to identify in vivo...
- This federal Project Grant award of $249,000.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on the role of Sphingosine Kinase 1 (SPHK1) in the vascular smooth muscle cell hyperproliferation observed in Supravalvular Aortic Stenosis (SVAS) and Patent Ductus Arteriosus (PDA). The research aims to elucidate the mechanistic links between defective elastic lamellae and excessive smooth muscle cell accumulation in these...
- This Project Grant award of $506,803, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), will fund research by the Research Foundation for the State University of New York (RF SUNY) to develop advanced multiscale modeling capabilities for predicting thrombus (clot) formation and its response to external loads. The goal is to create computational tools that can better forecast clot growth and rupture under varying blood flow conditions, such as pulsatile...
This Project Grant award of $154,000 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research software engineering work for the SimVascular open-source project at Stanford University. The funding will enable Dr. David Parker, a Research Software Engineer in the Marsden Lab, to make essential contributions over a 3-year period from August 2025 to May 2028. This includes code improvements, development and integration of new features, enhancing the software architecture for sustainability and modularity, and providing dissemination and user community support. The SimVascular software is a crucial tool for patient-specific simulations of blood flow and tissue biomechanics, enabling high-impact cardiovascular research and over 1,000 related publications. This award will ensure continued advancement and sustainability of the SimVascular platform to support three ongoing NIH-funded R01 research projects at Stanford spanning adult to pediatric cardiovascular disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $154.0k | 8/13/25 |