Project Grant R44NS135645
- The National Institute of Neurological Disorders and Stroke awarded $435,979 to Aneuvas Technologies Inc. on September 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a novel biocompatible polymer coating for intracranial aneurysm treatment devices. The project will develop and optimize a polymeric coating (PPODA-QT) applied to nitinol flow diverters for endovascular aneurysm treatment. Current metal-based...
- The National Science Foundation awarded Life Seal Vascular Inc. a $1.25 million cooperative agreement on August 1, 2026, to advance design and testing of the CygNum aneurysm sac management device for endovascular repair of abdominal aortic aneurysms. The recipient will optimize the device's delivery system, verify long-term biocompatibility, and demonstrate reliable performance in laboratory and preclinical models. The technical approach combines a compressible implant with precise...
- The National Institute of Neurological Disorders and Stroke awarded Washington University in St. Louis $493,332 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a surface electroneurography device for in-office assessment of peripheral nerve recovery. Washington University partnered with Biocircuit Technologies to design a diagnostic system addressing limitations in current peripheral nerve injury...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Wynnvision LLC $612,630 on September 25, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop an amine gradient silicone ventricular catheter for treating ventriculoperitoneal shunt infections and blockages. Wynnvision will translate successful in-vitro studies on amine gradient silicone Foley catheters to develop amine gradient silicone ventricular...
- The National Institute of Neurological Disorders and Stroke awarded the Trustees of Boston University $173,128 on January 25, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop trehalose-based coacervates for biomolecular and cellular delivery to improve wound healing in spinal cord injury. The research addresses the challenge of delivering therapeutic molecules and grafted cells to spinal cord lesion sites while...
- This $274,547 Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop a novel Aneurysm Sealing Device (ASD) for endovascular treatment of Abdominal Aortic Aneurysms (AAA). The project seeks to create a device that can completely seal the aneurysm sac, reducing the risk of post-procedure complications and the need for repeat interventions. Key objectives include validating the device's adaptability...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded a cooperative agreement to The Johns Hopkins University for $749,720 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The funding supports development and preclinical testing of a sustained-delivery insulin-like growth factor 1 (IGF-1) therapeutic for...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Washington $212,265 on August 21, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a closed-loop system for personalizing transcutaneous spinal stimulation (TSCS) amplitude during locomotor rehabilitation for individuals with neurological impairments from spinal cord injury, stroke, multiple sclerosis, traumatic brain...
- The National Institute of Neurological Disorders and Stroke awarded Aneuryst Inc. $492,110 on September 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds enzyme phenotyping of hydroxyfasudil to support preclinical development work for potential treatment of cerebral vasospasm following subarachnoid hemorrhage. The research advances foundational understanding of fasudil, a Rho-kinase inhibitor used in Japan for...
- The National Institute of Neurological Disorders and Stroke awarded Neurovascular Diagnostics Inc. $697,054 on September 16, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to test a blood-based assay for detection and risk assessment of intracranial aneurysms in familial cases. Neurovascular Diagnostics will validate AneuscreenTM, a PCR-based assay that uses gene expression in stabilized whole blood to predict both the...
The National Institute of Neurological Disorders and Stroke awarded Patchclamp Medtech, Inc. $1,524,947 on July 27, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a novel medical device for sealing dural perforations in minimally invasive spinal and cranial surgery. Patchclamp Medtech will advance a Phase II prototype of an applicator system that delivers and secures a bioabsorbable graft-clasp assembly directly at the site of dural perforation, addressing postoperative cerebrospinal fluid leaks that complicate minimally invasive approaches. The device enables one-handed operation and achieves a watertight seal by placing the graft inside the dura and securing it externally with a bioabsorbable clasp. Phase I demonstrated feasibility through in vitro and in vivo testing, showing improvements in sealing time and effectiveness compared to traditional suturing, stapling, or conventional sealing methods. Phase II activities will include scaling manufacturing processes, refining designs based on surgeon feedback and anatomical model testing, and conducting GLP-compliant biocompatibility studies in relevant animal models to confirm long-term safety and efficacy for broader clinical applications. Performance takes place in Seattle, Washington, with work completing by June 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 7/28/26 |