Project Grant R44NS073417

Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development of a silent, whole-brain functional magnetic resonance imaging (fMRI) acquisition method called Looping Star. The $432,749 project, which runs from March 1, 2025 to January 31, 2029, aims to design and optimize the Looping Star fMRI acquisition to...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $314,113 to Physical Sciences Inc. (PSI) to develop and demonstrate a high-speed, multicolor confocal fluorescence imager. The goal is to create a tool that can simultaneously capture multi-wavelength signals and display separated or merged multicolor images and 3D stacks at over 140 Hz frame rate. This advanced imaging system will be...

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $185,625 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop a novel magnetic resonance imaging (MRI) excitation technique. The project aims to address the flip angle inhomogeneity problem in high-field 7 Tesla MRI...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under CFDA Program 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health", supports the development of a fast, comprehensive brain MRI technique. The $884,573 award aims to create an 8-minute brain MRI exam that captures a variety of quantitative and qualitative MRI contrasts, as well as time-resolved gadolinium-based enhancement, in order to...

The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...

The University of Minnesota was awarded a $3,972,414 Project Grant from the National Institute of Neurological Disorders and Stroke within the Department of Health and Human Services to develop an electro-optical multiphoton microscope. The microscope will leverage advances in electro-optical beam deflection to enable random-access multiphoton interrogation of neurons and synapses with sub-microsecond access times. This will allow neuroscientists to collect the simultaneous recordings needed...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $390,616 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the Regents of the University of Michigan for the development of layer-specific functional magnetic resonance imaging (fMRI) techniques for clinical 3 Tesla scanners. The goal is to improve signal-to-noise ratio and reduce scan time for layer-specific fMRI, which currently...

This three-year, $4.485 million project grant from the National Institute of Mental Health will develop protocols and workflows for a new imaging approach called Serial-Section Parallel Immunohistochemistry/Fluorescence In Situ Hybridization (SPIFISH). SPIFISH aims to enable highly multiplexed, high-resolution imaging of endogenous molecules in brain tissue. The approach physically subdivides tissue specimens into ultra-thin sections, two orders of magnitude smaller than a neuronal cell body, to...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (CFDA #93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, Davis to develop a miniature two-photon microscope that can simultaneously perform high-resolution calcium imaging and optogenetic manipulation of neural activity in freely-behaving mice. The project will integrate innovative beam forming techniques into a...