Project Grant R44HL132197

Starlight Cardiovascular, Inc. was awarded a $1,477,713 Project Grant from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program to develop the first FDA-approved stent designed specifically for ductus arteriosus. The ductus arteriosus is a natural blood vessel that remains open in infants born with certain congenital heart defects; currently there are no stents approved for this use, forcing clinicians to repurpose adult coronary stents which have a high 47%...

Endoshape, Inc. was awarded a $370,938 project grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to develop radiopaque shape memory polymers for neurovascular embolotherapy applications. The Cardiovascular Diseases Research program aims to support heart and vascular research, including through competitive research training grants. Under this award, Endoshape will develop new radiopaque shape memory polymer materials incorporated into embolic coils....

Grant Award Summary Boston Children's Hospital received a $445,000 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded July 5, 2025, with a completion date of May 31, 2028. The grant supports research to advance airway stent design optimization through development of new ex vivo and in vivo models for tracheobronchomalacia, a rare...

This National Science Foundation (NSF) Small Business Technology Transfer (STTR) Phase I project aims to develop a novel, minimally invasive, bioabsorbable, steroid-eluting suture and surgical implant procedure to improve outcomes for 6 million patients suffering from rhinitis under the care of otolaryngologists. The $255,045 award, granted on September 15, 2023 under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, will fund the formulation of dissolvable polymers,...

This $136,924 National Science Foundation project grant supports the development of a smart stent for post-endovascular aneurysm repair surveillance at the University of South Florida. The key product to be delivered is a flexible, battery-less bioelectronic stent system that combines piezoelectric porous membrane sensors and microcoils for near-field magnetic induction communication. The smart stent will be woven with sensors inside and outside of a conventional stent graft to enable wireless...

Federal Grant Award Summary Nimble Surgical Incorporated received a $314,362 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for September 14, 2026. The company is developing FLEXLOCK, a novel manually-operable anchoring guide catheter designed to improve transradial complex percutaneous coronary interventions (PCI). The device features an innovative...

This federal Project Grant award for $220,000, provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), aims to deliver a comprehensive mathematical and computational framework for optimizing the design of next-generation stents. Key products and services to be provided under this 3-year award (August 1, 2024 to July 31, 2027) include: Developing a reduced model optimization module for the optimal...

Federal Grant Award Summary Aptus, LLC received a $965,037 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective September 1, 2025, through August 31, 2027. The award funds development of an expandable pediatric pulmonary heart valve device designed to address a critical clinical gap in treating infants and children born with severe heart valve defects. The research team, led by Dr. Leslie Sierad, Dr....

Federal Project Grant Award Summary Georgia TECH Research Corp received a $709,172 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through June 30, 2030. This award supports the development and validation of improved 3D-printed polycaprolactone (PCL) airway splints, referred to as Airway Support Devices (ASDs), for treating tracheobronchomalacia (TBM)—a congenital or acquired...

The National Heart, Lung, and Blood Institute (NHLBI) awarded Novomedix LLC a $306,872 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to develop novel oral small molecule therapeutics for the treatment of progressive pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF). The goal is to create a safer and more effective therapy compared to the currently approved drugs, which only slow disease progression and have significant side effects. Novomedix will...