This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop a revolutionary DNA sequencing platform that surpasses existing technologies in accuracy and cost. The $384,418 award to Xgenomes Corp. will fund the development of a super-resolution single-molecule sequencing method that can read short sequence "words" rather than single nucleotides, enabling highly accurate and cost-effective genomic analysis. The...
This federal Project Grant award, provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), supports the development and commercialization of an innovative technology called CytopeDrop by Survey Genomics, Inc. CytopeDrop enables high-throughput, spatially-resolved single-cell multiomics analysis, allowing researchers to simultaneously profile mRNA abundance, protein abundance, and cell locations. The $1,887,931 award, effective from...
The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $383,748 to Jumpcode Genomics Inc. to develop a CRISPR-based depletion technology to address pseudogene contamination in next-generation sequencing (NGS) used for newborn screening (NBS) genetic testing. The goal is to increase the sensitivity and specificity of detecting disease-causing genetic mutations by computationally designing CRISPR guide...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $295,923 to Avery Digital Data, Inc. to develop precision motion control and DNA fragment joining capabilities for an electronic nanochannel chip device. The goal is to greatly increase the availability of large, synthetic DNA constructs for biomedical researchers by creating a new, automated, and low-cost method of...
This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $314,538 to Dnali Data Technologies, Inc. to advance the commercial potential of a novel enzymatic technology for producing chemically modified synthetic DNA. The key objectives are: 1) creating modified DNA products that are not currently available from any existing vendor, 2) developing an innovation to eliminate the most costly reagent in the...
This $406,500 federal Project Grant from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), aims to advance "Next-Generation Mass Spectrometry-based Sequencing (NGMS-SEQ)" methods for high-throughput, bias-free sequencing and quantitative mapping of RNA modifications. The funded research seeks to: 1) enhance NGMS-SEQ techniques to directly sequence tRNA samples, including physiologically relevant ones, and 2) improve...
This Project Grant award, valued at $215,088, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research Federal Grant Program (CFDA 93.172). The grant supports the development of an "exhaustive de novo RNA sequencing method" by Directseq Biosciences, Inc., a small disadvantaged business based in Schenectady, New York. This innovative technology, referred to as Next-Generation Mass Spectrometry-based Sequencing (NGMS-SEQ), aims to...
This $900,000 Project Grant, awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CFDA 47.070) program, supports the development of custom hardware accelerators and software solutions to enable pervasive use of genome sequencing in precision healthcare. The three key objectives are: 1) designing domain-specific accelerators for whole genome sequencing and emerging genomics applications, 2) developing point-of-care pathogen detectors using real-time...
The National Human Genome Research Institute (NHGRI) awarded a $650,625 Project Grant (CFDA 93.172 - Human Genome Research) to The Broad Institute, Inc. to develop a novel platform called Helicase-Assisted Continuous Evolution (HACE) for performing multiplexed locus-specific hypermutation within the mammalian genome. This platform will utilize a nick-directed helicase fused to a deaminase domain to enable continuous mutagenesis across large genomic regions. The HACE system will be directed to...