Project Grant R44GM122149

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

The National Cancer Institute (NCI) awarded a $644,337 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the University of California, Los Angeles (UCLA) to study heterogeneity in [18F] FDG accumulation at the individual cell level using BetaBox technology. This 5-year research project aims to: Develop the next generation BetaBox technology to increase throughput and enable isolation of individual cells for further analysis; Characterize cell subpopulations...

This $1,507,500 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) is funding research at Yale University to investigate the regulatory mechanisms by which the genome encodes non-genetic heterogeneity in cell systems. The key objectives of the project are to: 1) identify transcription factor pairs whose combined activity at enhancers leads to transcriptional heterogeneity; 2) use a modified...

This $501,191.23 Project Grant awarded by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) supports research at the University of Texas MD Anderson Cancer Center to develop advanced computational models for analyzing single-cell genomics data. The key products and services to be delivered include: Creating a "single-cell gene-body associating domain (scGAD)" scoring system to explore 3D genome structures at the gene level and...

This Project Grant from the National Institutes of Health's National Cancer Institute totaling $668,151 will support the development of highly multiplexed live-cell G protein-coupled receptor (GPCR) arrays for glioma drug discovery. Spectragenetics, Inc. will deploy an automated multiplexed live-cell assay to detect and quantify agonist and inverse-agonist activities against 55 GPCRs known to be upregulated or downregulated in human gliomas. The assay will be used to screen 48 established...

This $554,653 Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports the development of "RARECYTEFINDER", a label-free, genome-wide copy number-based method for the unbiased identification and comprehensive molecular analysis of rare disseminated tumor cells (DTCs) in liquid and tissue biopsies. The key objectives of this 4-year project are to: 1) advance and validate the RARECYTEFINDER...

This Project Grant award from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $343,203 to Cyion Technologies LLC to develop a novel in vitro electrophysiology system for high-throughput measurement of intracellular action potential (IAP) in human-derived cardiomyocytes. The system leverages a 3D nanoelectrode array (NEA) technology to enable scalable recordings of IAP signals from many individual cardiomyocytes. This...

This $564,510 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will develop computational methods and tools to learn mechanisms in cell differentiation and development from complex, high-dimensional single-cell multi-omics data. The Georgia Tech Research Corporation will receive funding from September 1, 2022 to August 31, 2027 to analyze single-cell RNA sequencing, genome, chromatin accessibility, protein abundance and spatial location data. The...

This federal Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, provides $349,171 to Cellchorus Inc. to develop an integrated computer vision system called LF-TIMING (Label-Free TIMING). The goal is to enable large-scale, label-free profiling of cell-cell interactions, particularly between immune cells and tumor cells. The LF-TIMING system will leverage deep neural networks to accurately analyze phase-contrast video recordings,...

The National Human Genome Research Institute (NHGRI) awarded a $400,000 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Washington to develop new single-cell multi-omic technologies for studying the relationship between three-dimensional genome organization and gene expression. Specifically, the grant will fund the development of CARE-Seq, a novel method to jointly measure whole-genome chromatin interactions and gene expression in the same single cells from complex...