This federal Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, provides $349,171 to Cellchorus Inc. to develop an integrated computer vision system called LF-TIMING (Label-Free TIMING). The goal is to enable large-scale, label-free profiling of cell-cell interactions, particularly between immune cells and tumor cells. The LF-TIMING system will leverage deep neural networks to accurately analyze phase-contrast video recordings, allowing for improved cell segmentation, tracking, classification, and focus restoration without relying on fluorescent labeling. This will free up multiple fluorescent channels, reduce phototoxicity, and enable longer-duration, higher-frame-rate imaging of cell co-cultures. The project aims to deliver an AI-powered analytical platform that can quantify crucial cell-cell interaction events, such as contact patterns, frequencies, durations, cell death, and target cell killing behaviors, to enhance translational research capabilities and accelerate the development of novel cell-based therapies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $349.2k | 8/8/24 |