Project Grant R44DK099026

Acatechol, Inc. was awarded a $274,982 National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I grant to develop an innovative anti-infective coating for Foley catheters. The project aims to create a hybrid coating that combines biofilm-repellent and antimicrobial properties to provide prolonged resistance against pathogen colonization and catheter-associated urinary tract infections (CAUTIs). This work is being conducted under the NSF Technology, Innovation, and...

This Project Grant, awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a unique antimicrobial vascular catheter to prevent catheter-related bloodstream infections (CRBSI). The $272,702 award, effective September 1, 2023, with a completion date of February 29, 2024, will support research and development efforts to create an intravascular catheter with inherent long-lasting antiseptic properties. The...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a catheter end cap with an antimicrobial luminal insert to reduce the risk of bloodstream infections in hemodialysis patients. The $591,844 award to Allvivo Vascular, Inc. will fund the development and characterization of a prototype "Gatekeeper Antimicrobial Barrier...

This Project Grant award, titled "TARGETED ABLATION OF BLADDER-RESIDENT UROPATHOGENIC BACTERIA WITH A NOVEL CELL PENETRATING DYE", is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $249,951 award to the University of Texas at Dallas aims to develop a novel tool called "BACTVUE" that can selectively target and ablate bladder tissue...

This Project Grant award of $299,170 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to demonstrate the feasibility of a rapid, equitable antibiotic susceptibility test (AST) for urinary tract infections (UTIs). The goal is to develop the Metabolic Amino Acid Phenotyping (MAAP) test kit, which uses a lateral flow assay to provide susceptibility profiles for UTI-causing bacteria, including E....

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting a randomized Phase I/II pilot clinical trial to evaluate the safety, tolerability, feasibility, and efficacy of phage therapy for recurrent urinary tract infections (UTIs) in kidney transplant recipients. The $664,744 award will fund a study comparing intravenous phage...

This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to examine the role of Proteus mirabilis RTX proteins in the formation and pathogenesis of polymicrobial catheter-associated urinary tract infections (CAUTIs). The $299,608 award, with a period of performance from November 28, 2024 to May 31, 2027, will fund research to: 1) investigate the expression and...

The University of Florida was awarded a $650,000 Project Grant from the United States Department of Agriculture National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) competitive grants program. The four-year project aims to identify gut microbes and anti-adhesive urinary biomarkers that significantly contribute to preventing the adhesion of uropathogenic Escherichia coli (UPEC) in women. Over 30 previous clinical trials examining cranberry juice's...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $658,800 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Research Foundation For The State University Of New York to study the urothelial glycosaminoglycan layer and its role in catheter-associated urinary tract infections (CAUTIs). The project aims to comprehensively examine glycosaminoglycan composition in the urinary tract, define the...

This $1.23 million Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Loyola University of Chicago from June 2022 to May 2025 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to further the university's investigation into how certain species of Lactobacillus bacteria found in the female urinary tract can control colonization of uropathogenic Escherichia coli (UPEC) through...