This federal Project Grant award of $658,800.00 was issued on Jun 13, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at The Research Foundation for the State University of New York (RF SUNY) to investigate the composition and role of the glycosaminoglycan (GAG) layer in the urothelium, which is the site of initial host-pathogen interactions in the urinary tract. The project aims to comprehensively examine GAG composition, define the expression and substrate specificity of six putative GAG-degrading enzymes from two common catheter-associated urinary tract infection (CAUTI) pathogens, and determine the contribution of these enzymes to CAUTI progression and severity. Two sub-awards were issued to the University College London and the University of Texas at Dallas to collaborate on various aspects of the research.
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