This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $550,296 to develop a multimodal imaging-based diagnostic system for accurately assessing the risk of precancerous oral lesions. The key products/services to be delivered include: Development of machine learning (ML) and deep learning (DL) models using Fourier transform infrared (FTIR) imaging to stratify oral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) aims to develop an intraoral camera system that can detect and monitor early-stage dental caries (tooth decay) using targeted fluorescent nanoparticles and artificial intelligence (AI) software. The $294,632 award to Greenmark Biomedical Inc. will fund the development and optimization of a minimally viable product...
This Project Grant award of $409,403.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), supports the development of a comprehensive qPCR-based oral microbiome profiling platform by Branchpoint Biosciences Inc. The key objectives are to (1) determine the optimal oral microbiome targets by analyzing public metagenomic data, and (2) design and validate qPCR assays to accurately screen the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,347 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to Light Research Inc., a small business in Tucson, Arizona, to optimize and commercialize a compact multimodal intraoral camera. This innovative device integrates polarized white light imaging, autofluorescence imaging, optical coherence tomography, and near-infrared transillumination modalities to improve the sensitivity and specificity in...
This $162,216 Federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to investigate microbe-microbe interactions within the oral microbiome at the single-cell level. The key products and services to be delivered through this award include: Developing an approach that combines multiplex FISH imaging with expansion microscopy to study the spatial organization and functional...
This federal Project Grant award for $234,000.00, issued by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the functional roles and mechanisms of the human microbiome in oral squamous cell carcinoma (OSCC) pathogenesis. The study aims to define OSCC-associated metagenomic and metabolomic signatures, and determine whether microbiota transfer from human OSCC cases to mouse...
The federal Project Grant award R43DE034322 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The $306,633 award to Ther-Ai LLC will fund the development of the CraniaMaps software suite, specifically the CraniaMap module. This module is designed to enhance the auto-segmentation and landmarking of cone-beam computed tomography (CBCT) scans, which are critical for accurate diagnosis, treatment...
This $799,270 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel class of anticancer drugs called 1,3-thioureas for the treatment of oral squamous cell carcinoma (OSCC). The awardee, Keraceuticals, Inc., is formulating the lead compound CIDD99 for oral and/or intravenous administration, and will evaluate its efficacy as a standalone treatment or in...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $148,568 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan. The 18-month project aims to develop innovative biomarkers and a machine learning classifier to improve the characterization and monitoring of periodontal inflammation using quantitative ultrasound and image texture analysis techniques. Specifically, the research will investigate...
This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding the development of a novel optical pH imaging device to detect early-stage tooth decay. The $309,428 award to Veravanti Inc., a self-certified small disadvantaged business, will support the fabrication of a prototype optical pH (OPH) device that can rapidly and accurately map oral biofilm pH levels....
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,178,476 to Oraliva, Inc. to develop an AI-linked cytomics-on-a-chip tool for identifying and managing oral lichenoid lesions in primary care settings. The key products to be delivered include: 1) designing and producing alpha instrumentation units for research and commercial use, 2) defining optimal cytosignatures to differentiate between lesion types, 3) compiling a cytopathology database and developing new AI diagnostic models, 4) creating a clinically actionable, cloud-based report on lesion status, and 5) defining requirements for a future regulated point-of-care platform. This project aims to address the critical need for more accessible and accurate screening tools to enable early detection and effective management of oral precancerous conditions, which have a high malignant transformation rate. The award period is from April 2025 to March 2027.