All-in-one device for forensic toxicology drug screening
Ended Project Grant Awarded Last action
- Award ID
- R44DA056319
- Recipient
-
WIK Devices LLC UEI L5HXKEKQGL93
- Awarding agency
-
National Institute on Drug Abuse
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,281,842
Award facts
- Assistance listing
- 93.279 Drug Use and Addiction Research Programs
- Completion date
- Originally
- Place of performance
- Indiana, USA
Award details come from USAspending.gov.
Description
- Abstract
- Drug screening in toxicology cases is performed mainly using immunoassays, gas- chromatography mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS). Immunoassays lack the sensitivity, multiplexing capability, and flexibility to respond to the rise of potent synthetic drugs including fentanyl analogs and synthetic cannabinoids. GC- MS requires extensive sample preparation including derivatization reactions to achieve adequate performance. LC-MS, despite being a mature technology, is still not used by most labs for drug screening due to is high cost and complexity. We therefore see a both a technical and market need for better drug screening technologies that combine the simplicity and automation of immunoassays with the high sensitivity and specificity of mass spectrometry. In this fast-track (combined phase i and phase II) proposal, we seek to develop a mass spectrometry-based drug screening system utilizing paper spray mass spectrometry. The outcomes of this project will include two disposable cartridge devices which perform sample collection, storage, extraction, and ionization for MS detection. In addition to the disposable devices, we will also develop a simple manually operated and a second automated mass spectrometer interface which will enable analysis of the sample analysis cartridge on commercially available mass spectrometers. Finally, we will create instrument control and data analysis software package to provide a complete, end- to-end solution for drug screening. In phase i of this proposal, a prototype for the disposable paper spray analysis cartridge as well as the manual mass spectrometry interface will be developed and tested. If the performance of the analysis cartridge and interface are adequate for screening a representative set of synthetic drugs, we will proceed to phase II. In the second phase, we will improve the sample analysis cartridge, develop a sample collection device which will enable robust collection of a known volume of blood from an unspecified initial volume, develop the automated MS interface, develop needed control and data analysis software, and test the performance of the approach on both high resolution and low resolution mass spectrometers.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $836,432 | |
| Amendment | $889,695 | |
| Amendment | $889,695 | |
| Amendment | $889,695 | |
| Amendment | $258,775 | |
| Amendment | $258,775 | |
| Original award | $258,775 |
Quick answers
Who received award R44DA056319?
R44DA056319 was awarded to WIK Devices LLC by National Institute on Drug Abuse (National Institutes of Health) on May 1, 2022.
How much is award R44DA056319 worth?
$4,281,842 has been obligated on R44DA056319.
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