Project Grant R44CA314728
- The National Cancer Institute awarded Northeastern University $1,144,692 on September 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for precision cancer microsurgery using laser ablation-cooling with pulse bursts. The project develops a novel handheld microsurgical device that integrates video cellular-resolution microendoscopy with high-speed pulsed laser ablation to enable rapid visualization and eradication of microscopic tumor deposits at surgical margins...
- The National Institutes of Health National Cancer Institute awarded The Medical College of Wisconsin, Inc. $413,808 on August 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop and test a stimulation protocol using a wireless cranial implant to induce neuroplasticity and enable safer, more extensive surgical resection of gliomas that infiltrate critical brain regions. The recipient will develop a disruptive stimulation protocol using the FDA-approved Responsive...
- The National Cancer Institute awarded Dartmouth-Hitchcock Clinic $633,819 on September 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate advanced imaging techniques for laser interstitial thermal therapy (LITT) in the treatment of spinal metastases. The project addresses two critical technical barriers limiting clinical adoption of LITT for spinal tumors: inaccuracies in MRI thermometry caused by motion artifacts from respiration and cardiac...
- The National Cancer Institute awarded Rheotek Medical Inc. $1,045,569 under the Cancer Treatment Research program (CFDA 93.395) on September 1, 2026 for development of an ultra-precise needle delivery system for cutaneous cancer treatment. Rheotek Medical is developing the SoftTouch device, an automated intratumoral immunotherapy delivery system designed to address precision limitations in current manual injection methods for skin cancer. The device uses a miniaturized voice coil actuator to...
- The National Institutes of Health National Cancer Institute awarded The Leland Stanford Junior University $395,973 on June 9, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate an augmented reality system that projects volumetric MRI data inside the breast to guide lumpectomy surgery and reduce positive margin rates. The project addresses the clinical problem that approximately half of women undergoing initial lumpectomy for newly diagnosed...
- The National Cancer Institute awarded Georgia TECH Research Corp $396,457 on July 6, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop synergistic blood-brain barrier delivery and selective treatment of malignant glioma using pulsed field ablation and indoximod. The project investigates H-FIRE (histotripsy for focal ablation by resonant expansion), a minimally invasive focal ablation technique utilizing low-energy, microsecond-long electric pulses to induce...
- The National Cancer Institute awarded Unandup, LLC $405,753 on September 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop improved magnetomotive embolization technology for hepatocellular carcinoma treatment. The award funds development of a magnetic particle-based embolization platform designed to address limitations of current trans-arterial embolization procedures. Conventional catheter-directed embolization, the gold standard for intermediate-stage hepatocellular...
- Federal Grant Award Summary Illuminant Surgical Inc. received a $1,107,943 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) awarded on September 12, 2025, with a completion date of August 31, 2027. This Phase II effort focuses on the continued development and validation of Skylight, a mixed-reality navigation platform designed to improve the accuracy and safety of image-guided biopsy procedures. The platform employs advanced...
- The National Institute of Biomedical Imaging and Bioengineering awarded Sloan-Kettering Institute for Cancer Research $636,110 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop motion-tolerant pediatric MRI technology that reduces anesthesia dependence in tumor imaging. The funded research develops deep learning reconstruction techniques combined with radial k-space acquisition to compensate for...
- The National Cancer Institute awarded the University of California, Los Angeles $640,956 on May 15, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an artificial intelligence-enhanced perfusion MRI imaging biomarker for predicting yttrium-90 microsphere distribution in radioembolization treatment of liver cancer. The project addresses the current limitation that determining how Y90 microspheres disperse in a tumor relies on labor-intensive tracking of...
The National Cancer Institute awarded $1,008,660 to Aim Medical Robotics Inc. on September 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate a commercial-grade MRI-compatible neurosurgical robotic system for minimally invasive laser interstitial thermal therapy (LITT) treatment of brain tumors. Aim Medical Robotics is refining and validating the AIM Robotic System, a compact robotic platform designed to complete the full LITT workflow entirely within an MRI suite, integrating intraoperative MRI-based visualization, thermal imaging, and robotic actuation for precise probe placement and tumor ablation. The system eliminates the need for frame-based bolt placement and patient transfer between operating rooms and MRI suites, addressing current limitations in instrument placement accuracy, real-time visualization, and registration errors that have prevented MRI-guided LITT from achieving its full therapeutic potential. Under this Phase II SBIR direct award, the recipient will conduct human factors and workflow studies with neurosurgeons to define user requirements and optimize the clinical interface; refine and integrate the robotic manipulator, controller, software, and registration methods; and conduct a first-in-human feasibility study to validate the system's MRI safety and submillimeter accuracy in clinical use. The award runs through August 31, 2028, with place of performance in Worcester, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/25/26 |