Project Grant R43NS134446
Award Date
9/1/24
Completion Date
8/31/26
Dollars Obligated
$494K
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Hingham, MA 02043, USA
Similar Awards
This $1,369,242 project grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop an adeno-associated virus (AAV) gene therapy product for treating Mucopolysaccharidosis (MPS) IIIB, a rare lysosomal storage disease. The key objectives are to: 1) Engineer and optimize large-scale manufacturing processes for the AAV9-based gene therapy vector...
This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $2,208,982 to the San Diego Biomedical Research Institute to conduct research on the role of interleukin-13 (IL-13) and its receptor IL-13RA1 in the pathogenesis of Parkinson's disease. The research aims to elucidate the molecular and cellular mechanisms by which...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Brainstorm Therapeutics, Inc. aims to develop and validate a novel Parkinson's disease drug discovery platform using patient-derived midbrain organoids. The platform will guide therapeutic candidate identification, patient selection, and trial endpoint refinement to accelerate the development of effective disease-modifying Parkinson's treatments. Key innovations...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $655,329 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Albert Einstein College of Medicine in Bronx, NY. The grant will fund research to determine the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The research will integrate genome-wide association study data with epigenetic...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on investigating the cellular and molecular mechanisms underlying levodopa-induced dyskinesia (LID) in Parkinson's disease. The $350,036 award to the University of Alabama at Birmingham aims to characterize the unique transcriptional, physical, and physiological changes...
This $173,140 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at the University of California, San Francisco (UCSF) to elucidate the role of neural activity in the degeneration of midbrain dopamine neurons associated with Parkinson's disease. The project aims to utilize novel mouse models to chronically manipulate the...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a multi-year investigation into the mechanisms by which regulatory genetic variation influences the risk and progression of Parkinson's disease (PD). The $635,430 award to The Johns Hopkins University will enable researchers to define the chromatin and transcriptional...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $799,127 to Baylor College of Medicine to develop a novel "nano scavenger" agent for potential diagnostic and therapeutic applications in Parkinson's disease (PD). The project aims to establish the preclinical efficacy of this nano scavenger in profiling and potentially...