Project Grant R43NS115309

The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, awarded a $739,772 Project Grant to Cian, Inc. to develop a cilia biomarker kit for diagnosing and prognosticating traumatic brain injury (TBI) outcomes. The key products to be delivered through this 2-year grant are: 1) Developing specific monoclonal antibodies targeting two proteins expressed in cilia,...

The University of Pittsburgh was awarded a $2,888,616 Cooperative Agreement (U01NS131740) from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The purpose of this award is to conduct analytical validation of 7 emerging traumatic brain injury (TBI) biomarkers, including UCH-L1, GFAP, NFL, TAU, BD TAU, pTAU-181, and pTAU-231. The project aims to establish standard...

The U.S. Defense Health Agency has awarded a $1,395,898 Project Grant under the Military Medical Research and Development program (CFDA 12.420) to Medicortex Finland LTD for the project titled "POINT-OF-INJURY DIAGNOSIS OF TRAUMATIC BRAIN INJURY USING SALIVA". The 2-year grant, effective from June 15, 2024 to June 14, 2026, will fund research to develop a point-of-injury diagnostic tool for traumatic brain injury using saliva samples. This aligns with the program's objective of...

This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to evaluate the accuracy and feasibility of using point-of-care, low-field magnetic resonance imaging (POC LF-MRI) systems for the diagnosis and management of traumatic brain injuries (TBIs) in children. The $213,750 award, which runs from August 1, 2024 to July 31, 2026, will fund a prospective, single-center observational study...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to advance the development of prognostic and monitoring biomarkers related to neutrophil-driven secondary brain injury in patients with spontaneous intracerebral hemorrhage (SICH). The $704,313 award to Trustees of Boston University will fund research to define and validate a...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $1,499,886 to Astrocyte Pharmaceuticals Inc. to advance the development of an oral tablet formulation of their proprietary small molecule pharmaceutical agent AST-004 for the treatment of moderate traumatic brain injury (TBI). The key objectives of this project are to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $404,100 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the role of receptor interacting protein kinase-1 (RIPK1) and interleukin-1 beta (IL-1β) signaling in driving chronic blood-brain barrier (BBB) damage and...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $245,625 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Johns Hopkins University. The grant, titled "DELTA ECMO ABI STUDY (ASSESSING ACUTE BRAIN INJURY AFTER RAPID REDUCTION OF PACO2 UPON ECMO CANNULATION USING PORTABLE MRI AND BIOMARKERS)", aims to investigate the link between rapid changes in carbon dioxide levels and acute brain injury in...

The University of Michigan will receive a $1,499,263 project grant award from the Department of the Army Medical Command to develop a microfluidics device for the measurement of traumatic brain injury biomarkers at the point of care. The three-year award, issued on September 15, 2022 under the Military Medical Research and Development program, will support the creation of a portable diagnostic tool to investigate medical solutions for traumatic brain injuries sustained on the battlefield. By...