Project Grant R43HG006656

This Project Grant awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $440,287 to GE Medical Systems Information Technologies, Inc. to establish a simplified and accessible procedure for multi-analyte simultaneous extraction of DNA, RNA, and protein from tumor touch imprints. This approach aims to democratize biobanking for low-resource institutes by enabling molecular analysis from smaller tumor samples, including those less than 10,000...

The National Institute of General Medical Sciences (NIGMS) awarded Attogene Corporation, a biotechnology company based in Austin, Texas, a $229,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop a rapid, portable, and sensitive test for detecting ribonucleases (RNases). The grant supports the company's efforts to create a novel lateral flow assay prototype that can quickly identify RNase contamination, which is critical for ensuring quality...

This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $383,482 to Electronic Biosciences, Inc. to develop the SPINSEQ platform, an innovative RNA sequencing technology. The goal is to create a highly precise and accurate solution for transcriptomic and epitranscriptomic analysis that can overcome the limitations of existing RNA sequencing methods. Key focus areas include maintaining RNA integrity, ensuring accurate sequencing,...

This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding the development of novel signal amplification technologies by Molecular Instruments, Inc. to enable automated, ultrasensitive, and multiplex imaging of RNA and protein expression in biological samples. The $1,099,625 award supports the engineering of two key capabilities: 1) a chromogenic signal amplification...

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will provide $215,088 to Directseq Biosciences, Inc. to develop an exhaustive de novo RNA sequencing method using next-generation mass spectrometry (NGMS-seq). The objective is to create a technology that can directly identify and sequence every RNA species in a sample, while also comprehensively profiling all RNA modifications, without bias....

This $339,300 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports Triangle Biotechnology's development of a nanodroplet-enhanced sonication technology called ChromExtract. The goal is to enable high-quality, high-yield, and consistent chromatin extraction from formalin-fixed, paraffin-embedded (FFPE) tissue samples for downstream chromatin profiling and accessibility analyses. The...

This $3.7 million project grant from the National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering will fund research at Arizona State University to develop RNA stabilizing elements that improve coronavirus diagnostics. Specifically, the university will model the role of 5' secondary structures in modulating mRNA stability, optimize sensing RNAs to detect SARS-CoV-2, and use degradable trans-acting RNAs to enhance sample and amplified RNA stability....

This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) is providing $1,020,280 to Vellum Biotechnology, Inc. to develop a new nucleic acid extraction technology to enable high-quality DNA sequencing from formalin-fixed, paraffin-embedded tissue (FFPET) samples. The project aims to create a more robust and scalable epitachophoresis (ETP) system that can improve the yield, quality, and length of purified nucleic acids extracted from...

This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $628,726 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Priogen Corp. to develop a portable, microfluidic device called Micro-QUIC for the rapid detection of misfolded prion proteins that cause transmissible spongiform encephalopathies (TSEs). The 2.5-month project, starting on May 15, 2025, aims to: (1) optimize the Micro-QUIC assay to distinguish between native and misfolded...