Project Grant R43HD097888

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,895 to Ricovr Healthcare Inc. to develop a rapid, low-cost, point-of-care (POC) diagnostic platform for quantitative measurement of placental growth factor (PlGF) to predict and detect pre-eclampsia. The goal is to create an objective, affordable POC tool to improve the clinical diagnosis and monitoring of pre-eclampsia, which...

This $550,000 Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development and validation of a non-invasive, multiplex blood test for the early detection of preeclampsia, a serious pregnancy complication. The project aims to advance the detection of vascular dysfunction, particularly preeclampsia, by optimizing a blood test that targets disease-inducing signaling proteins on the surface of...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $585,794 to Tele-Stethoscope Inc. to develop a novel mobile phone technology that can detect preeclampsia and hypertension. The key products and services to be delivered include: Demonstrating proof-of-concept that ordinary mobile phones can reproduce physicians' diagnoses of preeclampsia using acoustic hemodynamic data captured...

The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Brigham & Women's Hospital Inc. to develop a wearable, wireless device called CNAP-FlexNIRS that can continuously monitor non-invasive arterial blood pressure in neonates. The $237,827 award, which runs from December 2024 to November 2026, will fund the modification of the existing FlexNIRS device to measure pulsatile blood...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Akna Health Inc. a $151,600 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to develop a point-of-care diagnostic solution for early identification of high-risk pregnancies. The research aims to validate the clinical relevance of cervical biomarkers as predictors of perinatal complications, such as fetal growth restriction, miscarriage, and...

This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $747,911 to Women & Infants Hospital of Rhode Island to evaluate the effectiveness of the RI-SPHERES program, a technology-based collaborative care model that aims to reduce short- and long-term morbidity associated with hypertensive disorders of pregnancy (HDP). The program will provide postpartum patients with...

The National Science Foundation awarded Vena Vitals Inc. a $1 million cooperative agreement under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a wireless, continuous, non-invasive blood pressure monitoring device. The device aims to address the unmet need for real-time blood pressure monitoring of patients undergoing surgery or in critical care by capturing rapid fluctuations with high temporal resolution. Current technologies are limited in accuracy, cost...

The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...

Dynocardia Inc. received a $256,000 National Science Foundation Project Grant to advance development of a novel continuous, cuffless blood pressure monitoring device. Funded through the NSF Engineering Directorate's SBIR program, the award will support Dynocardia's efforts to address motion artifacts and enable accurate, beat-to-beat blood pressure measurements in hospital intensive care and operating room settings. Accurate 24-hour blood pressure monitoring has potential to significantly...

This $624,998 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of a point-of-care testing (POCT) instrument for highly sensitive and near-real-time perinatal monitoring of oxytocin levels. The awardee, Giner Inc., a small business research and development firm in Massachusetts, will build upon preliminary results and the company's prior...