Project Grant R43HD083083

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $295,247 will support the development of an innovative medical technology for localized and sustained antibiotic treatment of periprosthetic joint infection. Specifically, the awardee Reselute will design, develop, and validate a proof of concept for an orthopedic spacer implant with a novel porous medium capable of controlled antibiotic elution over 180 days. The implantable...

Acatechol, Inc. was awarded a $274,982 National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I grant to develop an innovative anti-infective coating for Foley catheters. The project aims to create a hybrid coating that combines biofilm-repellent and antimicrobial properties to provide prolonged resistance against pathogen colonization and catheter-associated urinary tract infections (CAUTIs). This work is being conducted under the NSF Technology, Innovation, and...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $314,362 to Reselute, Inc. to develop the ReselutionTM Hindfoot Intramedullary Nail. The goal of this project is to create a combination implant that integrates structural support with sustained local antibiotic delivery to prevent infections while stabilizing fractures and fusions in...

This Project Grant, awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a unique antimicrobial vascular catheter to prevent catheter-related bloodstream infections (CRBSI). The $272,702 award, effective September 1, 2023, with a completion date of February 29, 2024, will support research and development efforts to create an intravascular catheter with inherent long-lasting antiseptic properties. The...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is focused on the development of a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by reducing or eliminating them through the use of this biocompatible and antimicrobial nano-biological coating. The $305,000...

This Project Grant award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program will fund the development of an advanced wound care product to treat diabetic foot ulcers. The $305,000 award to Therapeutic Bandage Products, Inc. will support the creation of a patented microneedle bandage that delivers three therapeutic agents to disinfect the wound, prevent bacterial biofilm formation, and attract white blood cells to aid healing. This...

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $625,909 to The Leland Stanford Junior University to develop a hydrogel platform technology for delivering topical bacteriophage therapy to treat antibiotic-resistant Pseudomonas aeruginosa infections, particularly in chronic wounds. The project aims to create a...

This National Science Foundation (NSF) Small Business Technology Transfer (STTR) Phase I project aims to develop a novel prescription process for customizing prosthetic feet based on individual patient characteristics. The $274,975 award, granted on September 15, 2023, will enable the awardee, Little Room Innovations LLC, to create a system that utilizes adjustable prosthetic foot prototypes and optimization algorithms to determine optimal mechanical properties for each patient's customized...

This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) is providing $323,850.00 to Watershed Medical Inc. to develop an innovative drug delivery platform for local delivery of the antibiotic amikacin to the bladder. The goal is to create a prophylactic solution to treat and prevent recurrent urinary tract infections (rUTIs) in post-menopausal women. Initial human studies have demonstrated the product's...

The National Science Foundation (NSF) awarded a $275,000 Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Auxilium Health, Inc. for the development and validation of an aerogel-based biomaterial wound dressing. The proposed innovation aims to create a multi-layer wound dressing platform with integrated fluid management, biofilm prevention, and rapid infection detection capabilities to improve the management of acute wounds, chronic wounds, surgical...