Project Grant R43GM159932
- The National Institute of General Medical Sciences (NIGMS) awarded Fluorofinder, LLC a $356,190 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to advance a novel microscopy workflow tool. The tool is designed to streamline assay development, improve awareness and education around optimal selection of microscopy assay components (instruments and reagents), and enhance reproducibility in the field. The project aims to address common challenges in...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This $306,788 federal Project Grant was awarded on September 30, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports the development of advanced probe technologies for ultrasensitive, quantitative RNA imaging using Hybridization Chain Reaction (HCR) amplification methods. The research aims to enable multiplexed, high-resolution imaging of gene expression patterns in highly autofluorescent...
- This federal Project Grant award of $349,280 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of advanced machine learning algorithms for ultra-high-density, ultra-high-precision single molecule localization microscopy (SMLM). The grant recipient, Xgenomes Corp., will create a SMLM video simulator to generate training data (Aim 1), build a machine learning-based grouping...
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- The federal Project Grant award of $338,843 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to Nanoengineering Corporation (UEI: SL7BYLYTR6A1) for the project "Soft-Landing of Size-Separated Macromolecules for Structural Analysis by Cryo-TEM". The project aims to develop an electrospray differential mobility analysis (ES-DMA) soft landing system to enable higher-resolution cryogenic...
- This federal Project Grant award, totaling $850,740 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to significantly expand fluorescence spectral multiplexing in tissue imaging. The key objectives are to: Develop a 56-color panel of semiconducting polymer dots (PDots) with narrow absorption and emission bands to enable 56-plex imaging for deep immune profiling of cells in tissue samples....
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded a $1 Project Grant to Vanderbilt University to purchase a super-resolution microscope to support extracellular vesicle (EV) and nanoparticle research. The ONI NanoImager microscope provides sub-20 nanometer resolution for characterizing nanoscale structures, with capabilities for single-molecule localization microscopy, single-molecule FRET, and...
- The federal Project Grant award of $621,500 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The goal of the project is to develop new methods for combined molecular and ultrastructural imaging of neural cells and tissues using advanced nanoprobes and cathodoluminescent dyes. Specifically, the award will fund the development of (1) detergent-free...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $349,681 to the University of Maryland, College Park to develop force nanoprobes that can map intracellular forces in living cells. The goal is to advance the understanding of how cells process mechanical cues, which is critical for addressing diseases associated with dysregulated mechanical communication. The force...
This $306,872 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of a set of reagents that combine fluorescence tags with gold nanoparticle electron microscopy (EM) labels. These "correlative light and electron microscopy" (CLEM) reagents will enable highly multiplexed mapping and superresolution microscopy to better localize molecular interactions at the nanometer scale. The award recipient, Nanoprobes Inc., will systematically develop these CLEM reagents using different fluorophores and gold nanoparticle sizes, with both biorthogonal and conventional conjugation chemistries. The reagents will be evaluated in experimental systems studying correlative fluorescence and chromatin electron microscopy tomography. This work aims to address the unmet need for truly correlative, multiplexed labeling technologies to fully realize the potential of CLEM for understanding cellular structure and function.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.9k | 8/29/25 |