Project Grant R43GM133228

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $450,000 Project Grant to the Texas A&M Engineering Experiment Station (Tees) to develop an injectable, grain-of-rice size glucose biosensor for continuous blood sugar monitoring. The key products or services to be provided under this 3-year grant include: Developing an injectable glucose biosensor comprised of a self-cleaning membrane and a near-infrared fluorescence...

This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...

This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $762,960 to the University of Texas at Austin to develop small, single-fluorescent protein biosensors that can precisely measure concentrations of specific metabolic signaling intermediates within cells. The purpose is to elucidate the mechanisms by which the availability and regulation of these metabolites impact enzymatic...

Zymosense Inc. received a $256,000 Project Grant award from the National Science Foundation Division of Industrial Innovation on December 1, 2021 to develop a platform for rapid assessment of hydrolytic enzyme activity to optimize their design and use. The award is being carried out under the Engineering program (CFDA 47.041) of the NSF Directorate for Engineering, which seeks to improve quality of life and economic strength through engineering research and innovation. Under this one-year...

The National Science Foundation (NSF) awarded a three-year, $449,999 Project Grant under their Engineering program (CFDA 47.041) to the University of Cincinnati to develop an implantable biosensor platform that can continuously monitor various biomarkers in the body for over a year. The project aims to create a new class of long-lasting aptamer-based sensors protected by robust porous oxide coatings, which would enable the first practical implantable monitoring system for managing chronic...

The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...

This $450,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to The Johns Hopkins University supports the development of a new "dual-series gate" organic electrochemical transistor (DS-OECT) biosensor technology. The key objectives include material synthesis, device fabrication, computer modeling, and biological fluid analysis to create a highly sensitive and stable sensor capable of reliably detecting protein biomarkers for various...

This $519,071 Project Grant, awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports research by Trustees of Boston University to develop optogenetic control strategies for metabolic engineering of microorganisms. The project aims to explore using light to control metabolic pathways, with the goal of balancing the production of valuable products and normal cell growth. The researchers will develop light-inducible proteins, comprehensively test light...

Michigan Technological University received a $199,972 Project Grant award from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering (47.041) federal grant program. The award will fund the development of an electrochemical sensor to simultaneously detect glucose and cortisol using an enzyme-free and antibody-free approach based on electrochemically polymerized molecularly imprinted polymers. The sensor aims to provide...