Project Grant R43DK145380
- This Project Grant award for $830,414 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to identify microbiome-derived sulfated metabolites and elucidate their effects on immune function. The research will leverage analytical chemistry pipelines developed by the awardee, President and Fellows of Harvard College, to detect sulfated compounds...
- This Project Grant award, in the amount of $126,846, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a translational research project to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The research, to be conducted at the University of Michigan, aims to identify gut bacteria...
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- This federal Project Grant award of $277,380.00, provided by the Office of the Director at the U.S. Department of Health and Human Services under the Trans-NIH Research Support program (CFDA 93.310), supports the development of novel statistical methods for detecting microbiome-metabolome interactions. The research aims to create a powerful transfer-learning framework for high-dimensional regression models to uncover associations between gut microbes and their metabolites, which play a...
- This federal Project Grant award of $358,039 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research by Nous Biosciences Inc. to evaluate a combination therapy of dolcanatide (a guanylate cyclase-C agonist) and atiprimod (a JAK-STAT inhibitor) for the treatment of murine colitis. The research aims to advance understanding of the pathogenesis of...
- This federal Project Grant award of $147,486 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research to investigate the role of gut microbes in regulating interleukin-22 (IL-22) levels in the pancreas and the impact on pancreatic health and disease. The research aims to determine how gut microbe-induced IL-22 affects pancreatic gene expression and the underlying cellular mechanisms, as well as the beneficial and detrimental effects of this...
- This federal Project Grant award of $790,359, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The research project aims to design, characterize, and optimize a fibronectin-targeting, nanobody...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,255,725 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The funding will support the development of a solid-state fermentation platform for manufacturing defined live biotherapeutic products (LBPs) comprised of in vitro manufactured bacterial strains. This represents a scalable approach to...
- This federal Project Grant award of $802,843, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Yale University to investigate the relationship between intestinal microbial activity and human metabolism. The key objectives are to: 1) understand how insulin resistance affects the adipose tissue lipolysis response to intestinal...
- This $835,564 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Utah to elucidate the mechanisms by which intestinal epithelial cells (IECs) interact with and regulate the gut microbiota to maintain intestinal homeostasis. Key objectives include investigating how IEC-derived...
This federal Project Grant award of $178,026 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, awarded to Inphasol Inc. in College Station, TX, aims to develop bacteriophages to target and reduce Desulfovibrio spp. bacteria in the gut microbiome. This is expected to reduce the production of hydrogen sulfide, which can contribute to malodorous flatulence and has been linked to conditions like ulcerative colitis and colorectal cancer. The 12-month project period runs from September 2025 to August 2026 and seeks to advance this targeted approach for modulating the gut microbiome composition and reducing hydrogen sulfide levels.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $178.0k | 9/5/25 |