Project Grant R01DK140810
Award Date 8/13/25
Completion Date 6/30/30
Dollars Obligated $830K
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
- This $421,250 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to elucidate how lifestyle factors such as diet, exercise, and social interactions shape the gut microbiome's contributions to human metabolic health. Over the 5-year grant period from September 2025 to June 2030, the research will be conducted by the President and Fellows of Harvard College. The...
- This Project Grant award, in the amount of $126,846, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a translational research project to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The research, to be conducted at the University of Michigan, aims to identify gut bacteria...
- This federal Project Grant award of $277,380.00, provided by the Office of the Director at the U.S. Department of Health and Human Services under the Trans-NIH Research Support program (CFDA 93.310), supports the development of novel statistical methods for detecting microbiome-metabolome interactions. The research aims to create a powerful transfer-learning framework for high-dimensional regression models to uncover associations between gut microbes and their metabolites, which play a...
- This federal Project Grant award of $178,026 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, awarded to Inphasol Inc. in College Station, TX, aims to develop bacteriophages to target and reduce Desulfovibrio spp. bacteria in the gut microbiome. This is expected to reduce the production of hydrogen sulfide, which can contribute to malodorous...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute in La Jolla, CA to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The researchers will employ chemical biology and proteomics methods to identify specific microbiota-associated bile acid protein targets in mammalian cells...
- The federal Project Grant award DP2GM154152, in the amount of $1,525,500.00, was provided by the National Institutes of Health (NIH) through the Trans-NIH Research Support program (CFDA 93.310). The award will support a project at Harvard Medical School to develop experimental and analytical approaches for capturing and quantifying "chemical epistasis" - the combinatorial effects of different small molecules in biological signaling and processes. The project aims to advance the...
- This federal Project Grant award of $802,843, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Yale University to investigate the relationship between intestinal microbial activity and human metabolism. The key objectives are to: 1) understand how insulin resistance affects the adipose tissue lipolysis response to intestinal...
- This $108,486 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to identify novel immune markers associated with obesity-driven diseases. The objective is to utilize novel tools to study the inter-organ communication pathway between the intestine and adipose tissue immune cells. The research leverages a Cre-inducible...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
- This Project Grant award of $403,750 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to unravel the relationships between gut microbial signatures, blood microbial signatures, and immune responses in sepsis patients. The research will integrate gut microbial community profiling, metabolomics, intestinal permeability measures, and blood microbial signatures with immune phenotypes and clinical...