Project Grant R01DK141070
- This federal Project Grant award of $458,047.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to understand how extracellular vesicles (EVs) from intestinal epithelial cells (enterocytes) mediate cell-to-cell communication and function as effectors of inflammation in inflammatory bowel disease (IBD). Specific objectives include identifying...
- This federal Project Grant award of $2,736,640.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Stanford University to characterize the diversity of innate lymphoid cell (ILC) subtypes and define their development, function, and spatial regulation in the gut. The objective is to exploit mechanisms that control distinct...
- This federal Project Grant award of $802,843, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Yale University to investigate the relationship between intestinal microbial activity and human metabolism. The key objectives are to: 1) understand how insulin resistance affects the adipose tissue lipolysis response to intestinal...
- This federal Project Grant award of $147,486 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research to investigate the role of gut microbes in regulating interleukin-22 (IL-22) levels in the pancreas and the impact on pancreatic health and disease. The research aims to determine how gut microbe-induced IL-22 affects pancreatic gene expression and the underlying cellular mechanisms, as well as the beneficial and detrimental effects of this...
- This federal Project Grant award of $183,600.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support a 5-year research and career development plan for the principal investigator, Dr. Amiko Uchida, to investigate how dietary changes impact the gut microbiome composition and function in patients with eosinophilic esophagitis (EoE), a chronic...
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- This federal Project Grant award of $112,026 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to The Washington University in St. Louis, Missouri. The award will support research to characterize the interactions between secretory IgA (sIgA) and the gut microbiome, particularly Akkermansia muciniphila, and how these relationships are impacted by autoimmunity...
- This $164,188 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The 5-year grant supports training and research at the University of Washington to study the role of intestinal chondroitin sulfate glycosaminoglycans in inflammatory bowel disease. The research aims to determine how changes in the composition of these gut matrix...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research focused on understanding the mechanisms that regulate lipid flux in cells and animals, and how crosstalk between gut immune cells and the absorptive epithelium impacts metabolic disease. The $761,399 award, effective September 1, 2025 through June 30, 2030, will...
- This Project Grant award of $116,625 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at the University of Iowa to investigate the epithelial-specific roles of the antioxidant protein Glutathione Peroxidase 1 (GPX1) in the intestinal microenvironment. The research aims to leverage the researchers' previous findings on the protective effects of GPX1...
This $835,564 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Utah to elucidate the mechanisms by which intestinal epithelial cells (IECs) interact with and regulate the gut microbiota to maintain intestinal homeostasis. Key objectives include investigating how IEC-derived extracellular vesicles (EVs) and the chaperone protein HSP90 mediate communication between IECs and commensal bacteria like Lactobacillus rhamnosus GG (LGG), and how these interactions influence the protective effects of LGG on IECs and gut inflammation. The award period runs from September 1, 2025 through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $835.6k | 8/21/25 |