Project Grant R43DK116503

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $687,416 Project Grant under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) to Lynntech Inc., a small business technology development company based in College Station, Texas. The grant will support the development of a cutaneous gel to deliver a therapeutic with an intriguing mechanism of action to effectively treat diabetic foot ulcers (DFUs). The project aims to: (1) prepare,...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Gelsana Therapeutics Inc. a $649,984 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop Provasliex Gel, a zwitterionic hydrogel that delivers controlled release of platelet-derived growth factor (PDGF). The goal is to improve wound healing for diabetic foot ulcers by reducing inflammation, promoting vascularization, and accelerating the wound...

This Project Grant award of $305,000 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of an advanced wound care product for treating diabetic foot ulcers. The product is a microneedle bandage that delivers three therapeutic agents to disinfect the wound, prevent bacterial biofilm re-formation, and activate the immune system to facilitate healing. Initial work will be conducted using skin tissue cultures and testing...

Vivonics Inc., a medical technology company based in Massachusetts, received a $331,455 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a near-infrared layered imaging system called NIR-LITH. This system aims to provide objective, three-dimensional hemodynamic mapping of diabetic foot ulcers and surrounding tissue with 1 mm depth resolution, improving clinicians' ability to assess wound healing potential and make more accurate...

This $367,577 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to Adepthera LLC aims to develop a regenerative peptide therapy to accelerate pressure ulcer healing. Specifically, the award will fund research to identify an optimal formulation of a self-assembling adrenomedullin (ADM) analog gel that can improve local blood circulation and wound healing in aging and diabetic mouse models. The proposed therapy would be administered weekly or biweekly via...

This $205,000 project grant from the National Institutes of Health's National Institute on Aging will fund research into the pathomechanics of diabetic foot ulcers at The University of Texas Southwestern Medical Center over a 12-month period. The research aims to identify more accurate markers and marker combinations for foot ulceration risk in patients with diabetic neuropathy and a history of prior ulcers. Using specialized equipment, the study will quantify two primary ulcer-causing...

This Project Grant award of $295,000.00 from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a novel implantable system leveraging distraction osteogenesis as a treatment for diabetic foot ulcers (DFUs). The project aims to design and develop a low-profile implantable transverse tibial transport device with an active mechanical mechanism to transversely distract or retract a cut tibia bone segment in a...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $425,176 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Eden Medical, Inc. to develop the "Smart Foot Mat" (SFM). The SFM is an in-home appliance designed to help prevent diabetic foot complications by allowing diabetic patients to monitor their foot oximetry and temperature on a daily basis. The grant funding will support the development of this novel...

This Project Grant award, titled "Comprehensive Assistance and Resources for Effective Diabetic Foot Navigation (CARE-D-FOOT-NAV), a Randomized Controlled Trial", was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $555,034 award, made on February 25, 2025, supports a randomized controlled trial to assess whether a comprehensive patient navigator...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $268,377.00 to The University of North Texas Health Science Center at Fort Worth to develop and evaluate a novel medical device using high-frequency, low amplitude vibration (HFLAV) for improving diabetic wound healing. The key objectives are to: 1) enhance and validate the HFLAV device by incorporating thermography to measure blood flow and tissue heat depth, and...