Project Grant R43DE034322

Award Date 4/1/25
Completion Date 12/31/25
Dollars Obligated $307K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Florida, USA
Similar Awards
This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful,...
This $556,548 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program supports the development of an artificial intelligence-driven system for online adaptive and personalized proton therapy. The project aims to: Build deep learning models for automatic online delineation of tumors and organs at risk on daily cone-beam CT images. Develop a patient-specific virtual replanner network using...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,347 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Light Research Inc., a small for-profit company based in Tucson, Arizona. The grant supports the development and optimization of a compact, multimodal intraoral camera system that integrates polarized white light imaging, autofluorescence imaging, optical coherence tomography, and near-infrared transillumination imaging...
This Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, will fund research into the genetic basis of human skeletal facial morphology through July 2025. Provided under the Oral Diseases and Disorders Research program (CFDA 93.121), the $936,510 in funding will support two key aims. First, the awardee will enhance current mesh landmarking procedures for craniofacial bone by developing a dense...
This R35 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 in funding to the University of Southern California (USC) to conduct comprehensive research on the mechanisms regulating skeletal connectivity in craniofacial development and disease. The 8-year project aims to advance scientific understanding of how diverse connective tissues in the craniofacial region...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $452,681 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of California, San Francisco (UCSF) to investigate the role of the ESCRT (Endosomal Sorting Complexes Required for Transport) machinery in regulating craniofacial morphogenesis. The 5-year project aims to determine the tissue-specific contributions of the ESCRT complex to mammalian craniofacial development, characterize how...
This $294,632 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to develop an intraoral camera system that can detect and monitor early-stage dental caries (tooth decay) using a novel fluorescent nanoparticle-based rinse. The grantee, Greenmark Biomedical Inc., will create a minimally viable product (MVP) of the intraoral camera system, which will collect white-light and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $250,931 to support the development and validation of a novel diagnostic modality for upper airway obstruction (UAO). The research aims to integrate dynamic computed tomography (4D-CT) imaging with computational fluid dynamics (CFD) analysis to create a quantitative, patient-specific assessment of UAO severity....
The University of Montana received a $294,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant, awarded on September 16, 2024, supports research to advance the understanding of mechanisms underlying craniofacial cartilage differentiation from human neural crest stem cells in 3D cultures. The goal is to develop the capability to generate functional, transplantable craniofacial...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will support research at Case Western Reserve University to investigate the role of fibronectin as a substrate for collective migration of calvarial osteoblast progenitors, and its impact on calvarial bone expansion and craniofacial disorders. The 5-year, $682,663 award will fund research activities aimed at...

The federal Project Grant award R43DE034322 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The $306,633 award to Ther-Ai LLC is funding the development of the CRANIAMAP software module, which is designed to enhance auto-segmentation and landmarking of cone beam computed tomography (CBCT) scans. This innovative AI-driven solution aims to improve the accuracy and efficiency of critical diagnostic processes in orthodontics, craniomaxillofacial surgery, and reconstructive procedures. The project's key objectives are to achieve at least 90% accuracy in auto-segmentation of cranial and facial structures, and maintain less than 2 mm mean square error in automated landmark identification across 250 diverse CBCT scans. The CRANIAMAP software represents a significant advancement in medical imaging technology, with the potential to benefit millions of patients requiring craniomaxillofacial, reconstructive, or orthodontic treatments.

Generated 4/8/25, 4:45 AM