Project Grant R43AG087901
- The National Institutes of Health (NIH) awarded a $628,753 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to SRI International, a non-profit research institute in Menlo Park, California. The grant aims to investigate the thermoregulatory physiology of menopausal hot flashes and evaluate whether localized peripheral cooling can mitigate these burdensome symptoms. The project will combine SRI's novel hot flash detection algorithm with a cooling approach developed by the...
- This $432,250 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research conducted by Beth Israel Deaconess Medical Center, Inc. (BIDMC) to investigate the role of the orexin neuropeptides in regulating sleep disturbances, anxiety, and hot flashes experienced by menopausal women. The research aims to elucidate the neuronal mechanisms by which chronically low estradiol levels disrupt the orexin system, leading to...
- The National Science Foundation awarded a $255,742 Project Grant to Lisa Health Inc. on May 15, 2021 for research toward developing the first novel multi-sensor smart wearable system for hot flash detection under the Engineering federal grant program (CFDA 47.041). Lisa Health will conduct research and development of a wearable device and associated software application utilizing multiple sensors to detect hot flashes and collect related physiological data. The project aims to provide an...
- This Project Grant award for $399,813 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports the development of the WHIM (Women's Health in Menopause) digital health product by Brightoutcome Inc. The product aims to improve the menopause experience for midlife women by extending Brightoutcome's existing GEMINI digital platform to include the MENOGAP patient education program and other enhancements. The project period runs from September 15, 2025 to August 31, 2026....
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development and validation of an Internet of Things-powered automated Cognitive Behavioral Therapy for Insomnia (CBTi) system to improve sleep quality and cognition in older adults. The $499,963 award will enable the awardee, Proactive Life Inc., to conduct a larger study on the feasibility of their "SleepSpace AI" system, which aims to increase adherence to CBTi through...
- This $275,765 Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program aims to develop and test prototypes of personal active cooling garments to protect at-risk patients from extreme heat waves. The grant is awarded to General Engineering & Research, L.L.C., a for-profit, economically disadvantaged woman-owned small business located in San Diego, California. The project will leverage the...
- This federal Project Grant award, provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), funds a research study on the relationship between menopausal vasomotor symptoms (hot flashes) and cardiovascular disease (CVD) risk in peri- and post-menopausal women. The $788,301 award supports a 5-year study that will investigate the mechanisms by which hot flashes may contribute to CVD risk, including through their impact on...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $298,883 to Iaterion, Inc. to develop a safer menopausal hormone therapy (MHT) formula that can be used long-term to treat protracted menopausal symptoms and prevent chronic diseases like osteoporosis, diabetes, obesity, and metabolic syndrome. The project aims to create an estradiol/reprogramming ligand combination that can potentially replace the progestin component of current MHT...
- This $880,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine the effects of daily stress, sleep, and sex hormones on accelerated vascular aging in premenopausal midlife women. The 2-year study, starting November 2024, will investigate how emotional reactivity to daily stressors and sleep variability contribute to vascular dysfunction prior to menopause, and how these factors interact with changes in estradiol levels. The...
- The National Institute on Aging (NIA) awarded a $506,399 Project Grant under the Aging Research program (CFDA 93.866) to Healthy Design LTD. CO. in Rutland, VT. The award, with an effective period of September 22, 2025 to September 21, 2026, will support the development of a "Novel Continuous Predictive Wearable Agitation Monitor and Alert Using Actigraphy and AI for Hospitalized Older Adults to Prevent Delirium and Dementia for Clinical Use and Harmonization of Research." The...
This $277,391 Project Grant award from the National Institute on Aging's (CFDA 93.866) Aging Research program supports Amira Health Inc.'s development and validation of TERRA, a closed-loop temperature control device designed to provide hot flash relief and improve sleep quality for menopausal women. The project aims to further evaluate TERRA's effectiveness at detecting and preemptively countering hot flashes through a comprehensive in-home study, with a focus on assessing the accuracy of its biometric detection system and the efficacy of its closed-loop cooling mechanism. Preliminary testing has demonstrated TERRA's potential to enhance sleep quality by rapidly cooling users in response to hot flash onset and dynamically adapting to their changing temperature needs across different sleep stages. This 1-year project grant, awarded on September 22, 2025, will enable Amira Health to advance the validation and commercialization of this innovative sleep technology for menopausal women.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $277.4k | 9/19/25 |