Project Grant R42GM163378
- This $306,782 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the continued development and validation of a panel of six sialoglycan-recognizing probes (SGRPs) by Z Biotech, LLC. The project aims to optimize these specialized molecular tools, which leverage naturally evolved microbial sialoglycan-binding proteins, for use in common laboratory techniques like ELISA, Western...
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- The University of Southern California received a $342,342 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for their project titled "CHEMISTRY-ENABLED GLYCOSCIENCE." The project aims to develop and apply chemistry-enabled approaches to address unresolved questions in the field of glycoscience, which studies the role of glycans (complex carbohydrates) in biological processes and...
- This federal Project Grant award of $390,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a versatile, small molecule-based platform to map the "reader proteins" of critical glycosylation, such as sialylation and core fucosylation. The research program seeks to decipher the protein-carbohydrate interaction code, particularly for disease-related interactions, to lay the...
- This $417,400 federal Project Grant was awarded on April 10, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Battelle Memorial Institute's Pacific Northwest National Laboratory. The grant supports the development and advancement of mass spectrometry imaging (MSI) tools to enable more accurate and comprehensive chemical characterization of the glycome (the complete repertoire of cell carbohydrates)...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $313,827 Project Grant to Lectenz Bio, Inc. in Georgia. The grant supports the development of "innovative glycan-specific reagents to accelerate the detection of disease biomarkers". Specifically, the project aims to engineer a high-affinity reagent derived from a glycan-processing enzyme to detect high-mannose glycans, which are known...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...
- This $457,088 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of imaging tools to improve the activity of endolysins, a promising alternative to traditional antibiotics for treating antibiotic-resistant bacterial infections. The key products and services to be delivered include: Synthesizing a panel of internally quenched substrates to assess the activity of...
- This $327,085 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of new tools and strategies to advance the understanding of lectin proteins and their roles in human health. The key objectives of this 1-year project include: 1) Creating tools to assess how soluble human lectins interact with and influence microbial communities, 2) Developing a...
- The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $325,500 project grant to Trustees of Boston College to support the chemical synthesis of biologically significant polysaccharides via living polymerization. The project aims to develop a platform for the scalable synthesis of various polysaccharides, including linear and branched glucan, mannan, arabinan, arabinomannan, poly-N-acetylglucosamine,...
This $315,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development of chemoenzymatic methods and reagents to produce affordable glycosphingolipids (GSLs), a class of lipids with complex carbohydrate structures that are ubiquitous in cell membranes. The key objectives are to: 1) expand the inventory of commercially available recombinant glycosyltransferase enzymes to enable the synthesis of 37 specific globo-/isoglobo- and lacto-/neolacto-series GSLs, and 2) optimize the large-scale synthesis and manufacturing of high-value GSL targets such as Globo H and sialyl Lewis A for anti-cancer therapy development, as well as GB3 for potential antibacterial applications. This project leverages an established collaboration between researchers at UC Davis and Integrated Micro-Chromatography Systems, Inc. (IMCS) to build upon prior advances that have reduced GSL material costs by over 400-fold.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $315.0k | 8/28/25 |