Project Grant R41TR006064
- Federal Grant Award Summary Nano-Beads Protein Innovations, Inc. received a $620,174 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded September 1, 2025, with completion expected by March 31, 2027. The project aims to develop NANO-AB, an innovative nanoscale biomaterial designed to advance monoclonal antibody (MAb) purification...
- Federal Project Grant Award Summary Protabit LLC received $304,602 in Project Grant funding from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, effective August 7, 2025, with completion targeted for July 31, 2026, supports the development of high-throughput engineering technologies for bispecific antibodies—therapeutic molecules that combine two different antigen-binding domains. The project...
- Federal Grant Award Summary Partillion Bioscience Corp received a $306,865 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of July 16, 2026 and completion date of June 30, 2027. The project focuses on advancing monoclonal antibody (mAb) discovery through enhanced development and commercialization of the company's proprietary nanovial technology—a hydrogel...
- Federal Project Grant Award Summary Goeppert LLC received a $350,000 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded July 1, 2026, with completion targeted for June 30, 2027. The grant funds development of NANO-PAVE (Nanopore-based Analysis of Proportion of Full and Empty Adeno-Associated Virus Capsids via Nanopore Evaluation), a solid-state nanopore platform designed to assess adeno-associated virus (AAV) capsid quality for gene therapy...
- Federal Grant Award Summary Potomac Affinity Proteins, LLC received a $377,602 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded July 1, 2026, with a completion date of June 30, 2027. The award funds development of a protease chain reaction (PROCR) technology designed to enable rapid, highly sensitive, and quantitative detection of biomolecules through simple mix-and-read assays. The...
- Federal Grant Award Summary Peptiforge, Inc. received a Phase 1 Small Business Innovation Research (SBIR) award of $306,872 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to develop a platform for rapid protein binder discovery. The award, effective September 1, 2025, through August 31, 2027, supports the establishment of a pipeline for developing therapeutically-viable protein scaffolds that bind specific...
- Federal Grant Award Summary Celdara Medical, LLC received a $310,564 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded July 1, 2026, with completion expected June 30, 2027. The award funds development of engineered regulatory T cells (Tregs) as a therapeutic intervention for Gaucher disease, a lysosomal storage disorder caused by deficiency of the enzyme glucocerebrosidase (GCase). The research leverages Tregs' unique capacity to cross the...
- Federal Grant Award Summary Door Pharmaceuticals received a $314,363 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2026, with a completion date of June 30, 2027. The grant supports the development and advancement of hepatitis B virus (HBV) antiviral molecules designed to suppress both viral replication and hepatitis B surface antigen (HBsAg) production. The research...
- Federal Grant Award Summary Precision Quantomics, Inc. received a $570,888 Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, with an award date of August 15, 2025 and completion date of August 14, 2026. This Phase I project aims to develop recombinant human enzyme panels that represent genetic variants in drug-metabolizing enzymes present in the U.S. patient population, with particular emphasis on populations carrying less common...
- Federal Grant Award Summary Kommodo Holdings Corp. received a $304,838 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on September 26, 2025, with completion targeted for August 31, 2026. The award supports the development of engineered memory T cells as a novel cell-based therapeutic platform to treat enzymopathies—diseases caused by missing or defective enzymes. The research...
Nabgen Inc. received a $312,461 Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350 (National Center for Advancing Translational Sciences), effective August 1, 2026 through July 31, 2027. The award funds the development of an engineered, long-acting Protein M derived from Mycoplasma to block alloantibodies (inhibitors) that develop in patients undergoing protein replacement therapy (PRT) for conditions such as lysosomal storage diseases and hemophilia. Preliminary data demonstrates that Protein M can reduce neutralizing antibody activity by 100- to 1,000-fold and offers universal functionality across mammalian immunoglobulins without impairing biologic potency or causing severe adverse effects in animal models. The project addresses a significant clinical and economic challenge: antidrug antibodies (ADA) that develop during PRT substantially increase treatment costs (5-fold higher) and result in more severe disease outcomes and increased hospitalizations. Unlike existing approaches such as B-cell or T-cell deletion, high-dose intravenous immunoglobulin (IVIG), or immune tolerance induction—which require prolonged management and often fail—the engineered Protein M strategy offers high efficiency, repeatability, and potential cost-effectiveness. Development activities include optimization of Protein M stability for room-temperature storage and further validation to support clinical applications in improving biological drug treatment outcomes for patients with inhibitors.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $312.5k | 7/8/26 |