Project Grant R41NS105263

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...

This federal Project Grant award of $377,875 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop a "one-two punch" strategy using engineered extracellular vesicles (EVs) to protect the blood-brain barrier (BBB) and improve outcomes in stroke. The primary goals are to: 1) deliver ATP5A and HSP27 proteins via the EVs to increase endothelial...

This Project Grant award, valued at $402,911.00, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant aims to develop a method for generating a large number of therapeutic nanovesicles (NVs) from mesenchymal stem cells (MSCs) using an extrusion process. These engineered "cell-drones" will be tested for their ability to promote tissue repair in mouse and porcine models of cardiac...

This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $299,982.00 to Unandup, LLC, a technology development firm based in St. Louis, Missouri. The funding will support the evaluation of safety and efficacy of Unandup's novel magnetic infusion platform for accelerating and improving the delivery of alteplase (tPA) to treat acute ischemic stroke....

This $4.4 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into developing a non-invasive stem cell-derived extracellular vesicle therapy for Alzheimer's disease. Over a three-year period from August 2022 to July 2025, researchers at Texas A&M University Health Science Center will test the hypothesis that intranasal administration of extracellular vesicles generated from human-induced pluripotent stem...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $296,108 to The Children's Hospital of Philadelphia (CHOP) to study the mechanisms of glial detection of axonal injury and facilitation of axonal regeneration. The project aims to define the origins of a novel glial response involving the release of large extracellular vesicles,...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate methods for converting scar-forming fibroblast cells into neurons after spinal cord injury. The goal is to restore lost neurons and repair neural circuits without cell transplantation. The $451,000 award to the University of Texas Southwestern Medical Center will fund research...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $2,130,388 to the University of Texas Health Science Center at Houston to conduct research addressing the paradox of poor outcomes despite successful recanalization in stroke. The key objectives are to: 1) Create a longitudinal clinical and imaging dataset to evaluate the role of final...

This Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $458,005 to Yale University to conduct research on determining the etiology and response to revascularization therapies for ischemic strokes caused by large vessel occlusion. The research, led by Principal Investigator Dr. James Giles, will utilize advanced transcriptomic...