This K23 award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will provide $227,445 in funding to Dr. James Giles at Yale University to conduct research on the cellular pathogenesis of stroke thrombi. The project aims to identify differences in the transcriptomic profiles of cells within acute stroke thrombi and paired blood samples to determine stroke etiology and response to revascularization therapies. By acquiring skills in computational biology, thrombosis biology, clinical translation, and research management, Dr. Giles will develop as an independent investigator capable of bridging computational biology and clinical research in vascular neurology. The research is expected to yield insights that can improve the efficacy of stroke revascularization therapies and diagnostic approaches for stroke etiology.
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