The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $470,786.00 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the role of extracellular mitochondria in age-related vascular cognitive impairment after stroke. The research aims to define the mechanisms by which...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to develop a non-invasive magnetic resonance imaging (MRI) technique to better evaluate tissue status and predict outcomes in acute ischemic stroke. The $492,749 award to the University of Pittsburgh supports the development and validation of a "Ratiometric Dual Contrast (RDUAL)...
This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
The University of Pittsburgh has been awarded a $428,400 federal Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to study the role of the astrocytic sodium bicarbonate transporter NBCE1 in regulating blood-brain barrier (BBB) integrity during ischemic stroke. The project aims to investigate whether pathological activation of NBCE1 in astrocyte endfeet contributes to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is focused on defining the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The $192,500 award to the University of Utah aims to (1) determine whether interventions targeting cerebral endothelial cells can improve stroke...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $608,787 to the University of California, San Diego to investigate a novel mechanism for how dysfunctional mitophagy (selective autophagy of mitochondria) contributes to brain ischemia-reperfusion injury. The research aims to determine if inactivation of the...
The federal Project Grant award R01NS136227 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $541,109 award will fund a clinical study at the University of Washington to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF)...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the CCL2/CCR2 signaling pathway in modulating HIV-associated ischemic stroke severity and recovery. The $422,125 award, effective from September 18, 2024 to August 31, 2026, will be conducted by the University of Miami. The research aims to...