Project Grant R41NS093756

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,499,886 to Astrocyte Pharmaceuticals Inc. to conduct preclinical efficacy and safety evaluation of their oral pharmaceutical agent AST-004 for the treatment of moderate traumatic brain injury (TBI). The goal is to develop an oral formulation of AST-004 that can improve...

This federal Project Grant award of $532,385 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and evaluation of a novel targeted nanotherapeutic delivery platform for treating brain disorders. The primary product being developed is a 2-deoxy-D-glucose (2DG)-based glycodendrimer nanoplatform (2DG-D) designed to selectively deliver...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), aims to map and characterize astrocyte network communication in the brain and investigate its role in facilitating neuroplasticity. The $141,102 grant, awarded to New York University, will fund research to develop a novel vector that can biotinylate molecules...

This federal Project Grant award of $446,126 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new bioassay to study astrocyte borders and profile their functional states in the context of diverse non-neural cell populations. The key objectives are to optimize the bioassay by combining injectable cellulose-based hydrogels with viral vectors to...

The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $379,171 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports a 2-year research project to investigate cerebrovascular dysfunction and cerebral atrophy in severe traumatic brain injury (STBI). Specifically, the project aims to: 1) Characterize...

This $453,860 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The grant, awarded to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences, aims to...

This $453,970 Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will support research by the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. to investigate the effects of intranasal HB-EGF treatment on brain glucose metabolism and inflammation following pediatric traumatic brain injury (TBI). The 2-year project aims to determine if HB-EGF...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...

This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...

This federal Project Grant award of $391,215 from the National Center for Complementary and Integrative Health (CFDA 93.213 - Research and Training in Complementary and Integrative Health) supports research into the mechanistic underpinnings of trigeminal nerve stimulation as a therapeutic approach for traumatic brain injury (TBI). The research seeks to utilize mouse experiments and numerical simulations to better understand how nerve stimulation reduces cerebral edema and improves functional...