Project Grant R41HL178334
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on developing novel bioengineered regenerative medicine solutions based on vasculogenic regenerative medicine technology. The $543,826 award, granted on December 10, 2024, aims to investigate the mechanisms underlying in vivo vasculogenic reprogramming, specifically examining...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $410,449 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to The Leland Stanford Junior University (Stanford University) on August 1, 2025. The funding supports research to develop novel synthetic biology strategies that would enable the quantitative and dynamic regulation of growth factors and cytokines produced from human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs). The goal...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $776,511 to the Fred Hutchinson Cancer Center (Seattle, WA) to develop a 3D engineered hemogenic vascular niche model that supports the induction of hematopoietic fates from human pluripotent stem cell-derived endothelium. The primary objective is to leverage this innovative platform to investigate how intrinsic arterial...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to define the role of the RNA-binding protein G3BP1 in blood vessel formation. The $147,486 award to Yale University will fund the development of a novel zebrafish model to investigate how G3BP1-mediated post-transcriptional regulation impacts vascular development. The overall objective is to enhance understanding of the gene regulatory networks...
- The federal Project Grant award titled "NICHE-SPECIFIC ENDOTHELIAL MECHANISMS REGULATING THE EXTRAVASATION OF HEMATOPOIETIC STEM CELLS" is funded by the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837). The $734,607 award, effective May 1, 2025 through February 28, 2030, supports research at Boston Medical Center Corporation to elucidate the key endothelial mechanisms that direct circulating hematopoietic stem cells across the...
- This Project Grant award of $528,179, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research conducted by the University of Miami to investigate reprogramming of monocytes to improve neovascularization in peripheral arterial disease and critical limb ischemia. The key objectives are to: 1) determine if extracellular vesicles mediate the systemic effects of monocyte reprogramming, and 2) investigate how reduced expression of the...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
- The National Heart Lung and Blood Institute (NHLBI), part of the U.S. National Institutes of Health (NIH), awarded a $460,625 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Yale University on August 10, 2025. The objective of this project is to develop highly tunable and customizable Tissue Engineered Vascular Conduits (TEVCs) using a novel bioprinting method that can directly print fully physiological materials, including cell-laden tissues. The project aims...
- This Project Grant award, valued at $748,965.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Northwestern University for a research project titled "Vascular Proliferative Resilience - Summary in Adults". The project aims to investigate the dynamics, spatial context, and molecular regulators of endothelial cell proliferation in the aorta, with the goal of deciphering the mechanisms underlying the maintenance of vascular...
This federal Project Grant award of $306,607, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113), aims to develop a novel approach for vascular regeneration using reprogrammed endothelial cells. The research project, conducted by Karis Bio USA, Inc., focuses on leveraging lineage-specific transcription factors to directly reprogram human dermal fibroblasts into endothelial cells. These reprogrammed endothelial cells have demonstrated the ability to induce neovascularization, provide pro-angiogenic effects, and improve blood flow in animal models. The project period runs from September 1, 2025 to August 31, 2026 and seeks to address the significant challenges in managing peripheral vascular diseases through innovative cell-based therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.6k | 8/20/25 |