This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $442,750 to the University of California, Davis to define a new model of evaporative dry eye disease (EDED). The research aims to: Define the clinical, topographical, and ultrastructural abnormalities of the ocular surface in AWAT2 knockout mice, which exhibit a dysfunctional tear film lipid layer similar to human EDED. Determine the impact of EDED on the corneal epithelial barrier...
This $251,250 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports research to characterize inflammatory cell infiltration in the meibomian glands and investigate the role of autoimmune CD4+ T cells in causing meibomian gland dysfunction (MGD), a leading cause of dry eye disease affecting millions. The award funds a collaborative research project between Baylor College of Medicine, which serves as the prime recipient, and the University of Houston College of...
The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $730,000 Project Grant (CFDA 93.867 - Vision Research) to Human Cell Co, a for-profit biotech firm, to develop an optimized nerve growth factor (NGF) therapy for the treatment of dry eye disease (DED). The funding will support preclinical studies to evaluate the efficacy and mechanism of action of the company's proprietary NGF mutein (HC201) in improving tear film production and corneal...
This Project Grant award of $422,199 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to explore a new therapeutic approach for treating meibomian gland dysfunction (MGD), a leading cause of dry eye disease. The research aims to investigate the use of estrogen receptor (ER) inhibitors, such as tamoxifen and fulvestrant, to suppress ER activity and increase androgen receptor (AR) function in the meibomian glands, with the goal of enhancing...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $356,485 to Stellular Bio, Inc. to scale up manufacturing and conduct Chemistry, Manufacturing, and Controls (CMC) studies for their regenerative therapeutic candidate STLR-201 to treat Sjögren's syndrome-related dry eye disease. The key products and services to be delivered under this award include: Finalizing the STLR-201 drug substance processing strategy and scaling up production to enable GMP...
This Project Grant award from the National Eye Institute (NEI) of the National Institutes of Health (CFDA 93.867 - Vision Research) provides $658,889 to the University of Rochester to investigate the role of the pro-inflammatory enzyme PLA2G2A/sPLA2-IIA in age-related macular degeneration (AMD). The research aims to utilize human donor eyes, patient-derived induced pluripotent stem cells, and transgenic mouse models to critically evaluate the mutation-independent pathogenic role of PLA2G2A in...
The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $143,569 Project Grant (CFDA 93.867 - Vision Research) to the Rochester Institute of Technology (RIT) to conduct research on the phase boundaries and liquid structure of concentrated eye lens protein mixtures. The key objectives of this 4-year research project (7/1/2025 - 6/30/2029) are to: (1) test predictions of molecular models of gamma crystallin interactions, (2) study how beta crystallin...
This Project Grant award for $383,000 from the National Eye Institute (CFDA 93.867 - Vision Research) aims to identify social determinants of health (SDOH) indicators associated with disparities in the diagnosis, management, and prognosis of dry eye disease. The project will leverage electronic health record data from a single-center and multi-center (Sight Outcomes Research Collaborative) datasets to build prognostic models that account for individual and structural barriers to accessing eye...
The National Eye Institute (NEI) awarded a $225,772 Project Grant (CFDA 93.867 - Vision Research) to The Research Foundation For The State University Of New York, doing business as Stony Brook University, to develop a terahertz time-domain spectroscopy (THz-TDS) imaging system that can accurately measure and map corneal hydration gradients. The project aims to: Determine the accuracy of the THz-TDS corneal scanner in measuring hydration levels in corneal phantoms and ex vivo models. Evaluate the...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) in the amount of $753,189 to Trustees of Boston University, doing business as Boston University Medical Campus, with a period of performance from August 1, 2024 to May 31, 2029. The grant will support research to identify novel therapeutic targets for corneal epithelial defects by revealing the differential roles of basal epithelial cells in the central cornea, limbus, and conjunctiva in corneal health and...