Development of a new drug for treating autoimmune uveitis
Ended Project Grant Awarded Last action
- Award ID
- R41EY033243
- Recipient
-
Abcon Therapeutics, Inc. UEI YE2GVFPK6577
- Awarding agency
-
National Eye Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $766,164
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date
- Originally
- Funding
-
- $510,776.00 Federal
- $255,388.00 Non-federal
- Place of performance
- Cleveland, OH 44106, USA
Award details come from USAspending.gov.
Description
- Abstract
- Autoimmune uveitis is a major cause of blindness in which retinal antigen-specific t cells lead to ocular inflammation and vision loss. Similar to the treatment of other t cell-mediated autoimmune diseases, selective suppression of the pathogenic t cells is the "holy grail" of therapeutic development. In pilot studies, we have developed a novel antibody-drug conjugate (ADC) with combined t cell targeting and potent anti-mitosis activity, which is designed to selectively kill the proliferating autoreactive t cells while sparing the other cells including normal t cells. In this phase i application, we will first demonstrate that this ADC selectively kills proliferating uveitogenic t cells while sparing normal t cells and other cells both in vitro and in vivo, then determine its in vivo treatment efficacy and potential off-target effects in two animal models of autoimmune uveitis. These studies will provide the required proof-of-concept for a phase II development of this promising ADC towards IND-enabling studies and further clinical development.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $255,388 | $0 | |
| Original award | $255,388 | $255,388 |
Quick answers
Who received award R41EY033243?
R41EY033243 was awarded to Abcon Therapeutics, Inc. by National Eye Institute (National Institutes of Health) on September 1, 2021.
How much is award R41EY033243 worth?
$766,164 has been obligated on R41EY033243: $510,776 in federal funding and $255,388 in non-federal funding.
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