Project Grant R41EB036383

Award Date 9/18/24
Completion Date 8/31/25
Dollars Obligated $374K
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Charleston, SC 29414, USA
Similar Awards
This $275,000 Small Business Technology Transfer (STTR) Phase I grant from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program) was awarded to Oncoblaze LLC to develop a novel device for targeted delivery of chemotherapy agents to tissue surrounding surgically removed tumors. The project aims to address the issue of tumor recurrence after cancer surgery, which affects 30-40% of patients for certain cancers. The device uses an infrared laser to heat...
This $381,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and evaluation of tumor-targeting polymeric micelles carrying a near-infrared (NIR) imaging agent. The goal is to provide real-time optical image guidance during brain cancer surgery to improve tumor resection and surgical outcomes. The project aims to: 1) develop and characterize the tumor-targeting polymeric...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Glow Therapeutics Inc. aims to advance a novel light-activatable nanoplatform for the targeted co-delivery of photodynamic therapy (PDT) and chemotherapy to treat peritoneal metastasis. The Phase I project will focus on developing a scalable manufacturing process, determining the optimal drug administration route, and identifying the PDT activation threshold for this...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program, is for the development of aerosolized microbots as a platform for targeted lung cancer therapy. The $416,796 award, granted on April 1, 2025, with a planned completion date of January 31, 2029, aims to identify magnetic field conditions for targeted...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is supporting the development of novel minimally invasive catheter-based devices for endovascular filtration. The goal is to create functional filters that can remove chemotherapy drugs from the blood in order to reduce systemic toxicity during locoregional infusion...
This $275,000 federal Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of Illuminate Therapeutics' Light Activated Drug Delivery and Release (LADDR) platform technology. The LADDR platform aims to enable precise spatiotemporal delivery of small therapeutic RNAs to tumors in head and neck and esophageal cancers, with the goal of preserving healthy tissues and reducing side effects compared to...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), provides $399,491 to Northridge Tri-Modality Imaging Inc. to upgrade their gantry-based imaging system to incorporate bioluminescence tomography (BLT) capabilities. The upgraded system will enable 3D whole-body fluorescent, bioluminescent, and anatomical X-ray imaging of small animal cancer models, providing a comprehensive multimodal imaging...
This Project Grant award from the National Cancer Institute (NCI), under the Federal Assistance Listings program CFDA 93.395 Cancer Treatment Research, provides $406,500.00 to support the development of a novel, low-cost, single-use trans-nasal cryotherapy device for esophageal cancer treatment in low-resource settings. The project aims to design and validate a functional prototype of this first-of-its-kind device, which would enable unsedated cryoablation procedures to be administered through...
The National Cancer Institute (NCI) awarded a $644,034 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a nanoparticle-based drug delivery platform that uses radiation therapy to control the sustained and localized release of chemotherapy agents within irradiated tumor tissue. The aim is to improve local disease control while mitigating systemic toxicities associated...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286), aims to develop and validate a wide-field fluorescence lifetime (FLT) imaging system for intraoperative imaging of sarcomas and other cancers. The $567,340 award to the Massachusetts Eye and Ear Infirmary will fund the creation of a portable, real-time FLT...

This federal Project Grant award of $374,095 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a device that uses an infrared laser to enable local delivery of a high dose of chemotherapy to the surgical cavity after tumor resection. The technology employs thermosensitive liposomal nanoparticles encapsulating chemotherapy agents that release the drug upon exposure to hyperthermia, allowing for a targeted, up to 25-fold higher local dose compared to systemic administration. The goal is to kill any remaining cancer cells after surgery and prevent local tumor recurrences. The award was granted to Oncoblaze LLC, located in Charleston, SC, and the project is expected to be completed by August 2025.

Generated 7/1/25, 2:57 AM