This federal Project Grant award of $374,095 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a device that uses an infrared laser to enable local delivery of a high dose of chemotherapy to the surgical cavity after tumor resection. The technology employs thermosensitive liposomal nanoparticles encapsulating chemotherapy agents that...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Technology Transfer (STTR) project grant, awarded to Vivosphere LLC, is developing a novel 3D tissue-engineered platform for cancer modeling and high-throughput drug screening. The $275,000 project aims to create a more physiologically relevant and scalable system to improve the translation of preclinical cancer drug candidates to clinical trials. Key objectives include testing...
This STTR Phase I project, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to advance the development and evaluation of a hand-held induction heater device for treating pancreatic and prostate cancer using magnetic fluid hyperthermia (MFH) technology. The project, awarded to Ihnnova LLC, a small business located in Guánica, Puerto Rico, will receive $275,000 in funding over the period of October 1, 2024 to...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) grant of $305,000 awarded to Redpoint Oncology, Inc. aims to develop and validate a novel platform for targeted cancer therapies. The project seeks to design and synthesize new therapeutic payloads that can selectively target and destroy therapy-resistant cancer cells. Research objectives include testing the effectiveness and selectivity of the payload...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Cerflux Inc. aims to develop a personalized cancer treatment screening platform. The project will establish guidelines for handling solid tumor biopsy samples, generate 3D bioprinted tumor models for validation, and demonstrate the platform's ability to match patients with the most effective cancer treatments before treatment begins. This innovative approach has the...
The National Science Foundation (NSF) awarded a $1,213,619 Cooperative Agreement under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Encapsulate Inc., a small disadvantaged business in Farmington, CT. This Phase II Small Business Innovation Research (SBIR) project aims to develop a precision oncology platform that integrates microfluidics, biochips, bioreactors, and 3D tumor models to predict patient-specific cancer drug responses. The proposed technology utilizes...
This $275,000 federal Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of Illuminate Therapeutics' Light Activated Drug Delivery and Release (LADDR) platform technology. The LADDR platform aims to enable precise spatiotemporal delivery of small therapeutic RNAs to tumors in head and neck and esophageal cancers, with the goal of preserving healthy tissues and reducing side effects compared to...
This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
This Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program provides $305,000 to support the development of a novel light-activatable nanoplatform for the targeted co-delivery of photodynamic therapy (PDT) and chemotherapy to treat peritoneal metastasis. The key objectives are to: 1) compare the pharmacokinetics and biodistribution of the nanoplatform following intravenous or intraperitoneal administration,...
This National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I project under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop an image-guided intratumoral delivery system for immunotherapies to treat solid tumors. The $305,000 award to Absco Therapeutics, Inc. (dba Abscotx) will fund the research and development of a biomaterial-based platform that can solidify upon injection to localize and sustain the release of biologics within...