This federal Project Grant, awarded by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), supports the development of a radiolabeled prostate-specific membrane antigen (PSMA) agent with reduced uptake in salivary glands. Tripill Biotechnology, Corp., a minority-owned small business, received $799,962 to partner with researchers and validate the therapeutic potential of the NOTA-UNC-PSMA2 agent, which has demonstrated 2-3 times higher tumor uptake and 10 times lower salivary gland uptake compared to the existing PSMA-617 agent in preliminary studies. The project aims to label the agent with copper isotopes (64Cu and 67Cu) and evaluate its stability, PSMA binding affinity, salivary gland uptake, and in vivo therapeutic efficacy. Successful development of this agent could significantly benefit prostate cancer management by reducing radiation exposure to normal organs while maintaining tumor-targeting ability.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 8/20/24 | ||
| Not listed | $400.0k | 7/17/24 | ||
| Not listed | $400.0k | 7/17/24 |