Project Grant R01DK140355
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $245,123 to support research on the role of vascular sympathetic neurons in brown adipose tissue and their impact on systemic metabolism. The project, led by The Trustees of Columbia University in the City of New York, aims to use novel genetic and chemogenetic tools, advanced...
- This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...
- This Project Grant award of $709,931 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), provided under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the role of neutrophils in regulating brown adipose tissue (BAT) function. The research aims to characterize how neutrophils are recruited to BAT and undergo metabolic and transcriptional changes in response to cold exposure, and to assess the impact of...
- This federal Project Grant award of $813,511 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the Dana-Farber Cancer Institute, Inc. (DFCI) to investigate the structural basis and functional consequences of thermogenic mitochondrial respiratory complexes assembly in the context of obesity and type 2 diabetes. The research aims to...
- This federal Project Grant award of $196,460 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to determine how inhibiting the migration of immature neutrophils during obesity affects hematopoietic stem and progenitor cells, metabolism, and systemic inflammation. The award, made on Jun 23, 2025, is to The Trustees of Columbia University in the...
- This federal Project Grant award of $464,985, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on extracellular vesicles released by adipocytes (fat cells) and their potential role in cardiometabolic disease. The research, conducted by The Washington University, aims to investigate how these adipocyte-derived extracellular vesicles, including...
- This federal Project Grant award of $1,225,749.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the Albert Einstein College of Medicine in Bronx, NY. The project aims to investigate the role of the Cyclin C (CCNC) protein and the Mediator complex in regulating adipose tissue remodeling and metabolic health. Key areas of focus include the impact of CCNC on...
- This Project Grant award of $307,508 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel bioengineered brown adipocyte (fat cell) transplant as a potential new therapy for treating obesity and associated metabolic disorders. The award will fund research by United Biotherapeutics LLC to further develop a safer and more efficient adeno-associated...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $773,112 Project Grant to Rockefeller University on September 5, 2025 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms of transcriptional control in adipocyte formation and function through nuclear receptor coactivators. The research aims to provide a better understanding of dysregulation in energy storage...
- This federal Project Grant award of $246,750.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), with a project period from August 15, 2025 to August 14, 2027. The award supports research by The Trustees of Columbia University in the City of New York to investigate how obesity affects the function of macrophages and T cells in the pancreas, and their role...
This $801,009 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research by The Trustees of Columbia University in the City of New York to study the role of vascular sympathetic neurons in brown adipose tissue and their effects on systemic metabolism. The research aims to utilize newly developed mouse genetic and chemogenetic tools, improved imaging techniques, and in vivo assays to examine how distinct subpopulations of sympathetic neurons that innervate brown adipose tissue regulate blood flow, thermogenesis, and glucose metabolism. The 5-year project, running from Sep 2025 to Jun 2030, will explore the hypothesis that vascular sympathetic neuron signaling can confer protection against obesity-induced metabolic dysfunction. The findings may advance understanding of the mechanisms regulating brown adipose tissue function and systemic metabolic processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $801.0k | 9/10/25 |