Project Grant R01DK142668
- This federal Project Grant award of $813,511 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the Dana-Farber Cancer Institute, Inc. (DFCI) to investigate the structural basis and functional consequences of thermogenic mitochondrial respiratory complexes assembly in the context of obesity and type 2 diabetes. The research aims to...
- This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...
- This Project Grant award of $307,508 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel bioengineered brown adipocyte (fat cell) transplant as a potential new therapy for treating obesity and associated metabolic disorders. The award will fund research by United Biotherapeutics LLC to further develop a safer and more efficient adeno-associated...
- This $801,009 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research by The Trustees of Columbia University in the City of New York to study the role of vascular sympathetic neurons in brown adipose tissue and their effects on systemic metabolism. The research aims to utilize newly developed mouse genetic and chemogenetic tools, improved imaging techniques, and in vivo assays to examine how distinct subpopulations of...
- This federal Project Grant award of $152,454 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the mechanistic role of the protein irisin in modulating immune response and adipose tissue dynamics. The primary awardee, Dana-Farber Cancer Institute, Inc., will conduct a multi-year study to: (1) elucidate the molecular pathways through which irisin...
- This $3,255,832 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research at the University of Chicago to investigate the role of macrophages in weight loss-induced metabolic health and adipose tissue inflammation resolution. The project aims to determine the phenotype, function, and transcriptome of visceral and subcutaneous adipose tissue macrophages across mouse and human models, as well as test strategies like cell...
- This Project Grant award of $709,931 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), provided under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the role of neutrophils in regulating brown adipose tissue (BAT) function. The research aims to characterize how neutrophils are recruited to BAT and undergo metabolic and transcriptional changes in response to cold exposure, and to assess the impact of...
- This federal Project Grant award of $803,748 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding research to investigate the modulation of insulin signaling in adipocytes (fat cells) and how improved adipocyte insulin sensitivity can contribute to positive metabolic outcomes. The research team at The University of Texas Southwestern Medical...
- The Dana-Farber Cancer Institute, Inc. (DFCI) was awarded a $840,198 Project Grant by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds research to better understand the mechanisms of energy expenditure in mammalian systems, with a focus on adipose thermogenesis. The research aims to identify the cellular and biochemical pathways by which the enzyme TNAP...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $773,112 Project Grant to Rockefeller University on September 5, 2025 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms of transcriptional control in adipocyte formation and function through nuclear receptor coactivators. The research aims to provide a better understanding of dysregulation in energy storage...
This federal Project Grant award for $849,788, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to investigate the role of hyaluronan (HA) in promoting new beige adipocyte development, which could enhance adipose tissue thermogenesis and energy expenditure. The Beckman Research Institute of the City of Hope, a nonprofit medical research organization in California, is conducting this research to explore how cold exposure and HA secretion by adipose progenitor cells stimulate the recruitment of new thermogenic beige adipocytes, as a novel approach to treating metabolic diseases. This 5-year project aims to elucidate the mechanisms by which HA regulates beige adipogenesis and develop strategies to target HA for improving metabolic health, particularly in aging populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $849.8k | 9/3/25 |