The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $115,707 Project Grant under the CFDA 93.173 Research Related to Deafness and Communication Disorders program to the Rector & Visitors of the University of Virginia (UVA). The grant supports research investigating how phospholipid homeostasis regulates hair cell function and health, using mouse models deficient in the phospholipid flippase ATP8B1 or its cofactor TMEM30B. The research aims to uncover the...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $262,001 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, which runs from September 30, 2024 to April 30, 2026, will fund research to investigate the underlying causes of "hidden" age-related hearing loss, which affects sound...
This federal Project Grant award of $610,725.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant will fund research at the University of Pittsburgh to investigate physiological mechanisms that contribute to suprathreshold deficits in speech understanding for individuals with sensorineural hearing loss. The key research activities include:...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $147,486 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The goal of this 2.5-year project is to identify the circuit mechanisms responsible for contrast-dependent perceptual changes and neuronal gain adaptation in the primary auditory...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $521,432 Project Grant under the CFDA 93.173 Research Related to Deafness and Communication Disorders program to the University of Rochester. The grant supports the development of a new computational model of the human auditory subcortex that integrates binaural processing and efferent gain control to investigate masking in complex sounds for both normal-hearing and hearing-impaired listeners. The research...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...
This Project Grant award of $623,777 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research on the role of the immune system and inflammation in hearing loss. The primary awardee, The Washington University, will conduct studies to examine how viral infections like cytomegalovirus (CMV) impact the development of the blood-labyrinth barrier in the inner ear and...
The National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded a $589,393 Project Grant to Northwestern University to support research on the development of cochlear innervation. The goal is to elucidate how the neural circuit in the mammalian cochlea assembles during development, by altering the identity of certain cell types involved. Through this project, the researchers will...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $581,105 to Creighton University to develop natural-based therapies for treating hearing loss caused by aminoglycoside antibiotics. The key focus is on designing, synthesizing, and testing piperlongumine derivatives that can better target the TRPV1 channel to protect hair cells and synapses...