This federal Project Grant award of $395,724, provided by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), supports research to develop a novel class of anti-cancer therapeutics known as "Abbapolins" that target the Polo-like Kinase 1 (PLK1) protein. The research aims to optimize Abbapolin lead compounds and investigate their activity against colorectal cancers, including testing them on patient-derived organoid models. The award was granted to PPI Pharmaceuticals LLC, located in Irmo, South Carolina, and the project period runs from August 1, 2025 to July 31, 2026. The goal is to lay the groundwork for preclinical and clinical development of the Abbapolin PLK1 inhibitors as potential colorectal cancer treatments with a unique mechanism of action.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $395.7k | 7/23/25 |