Project Grant R01CA295774

Award Date 1/9/25
Completion Date 12/31/29
Dollars Obligated $547K
Federal Grant Program
93.394
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $546,625.00 to the University of Pittsburgh to develop a novel nanocarrier-based immunochemotherapy for the treatment of metastatic colorectal cancer (mCRC). The key products and services to be delivered include:

  1. Developing and characterizing a nanoparticle carrier capable of co-delivering small interfering RNA targeting the IRHOM1 protein and a prodrug conjugate of camptothecin and SAHA. This combination therapy aims to enhance tumor growth inhibition and improve the tumor immune microenvironment in mCRC.

  2. Investigating the tumor-targeting efficiency, pharmacokinetics, and tissue biodistribution of the nanocarrier co-loaded with the IRHOM1 siRNA and CPT-SAHA prodrug.

  3. Evaluating the in vivo therapeutic efficacy, underlying mechanism, and toxicity profile of the nanoparticle-based combination therapy in murine and human mCRC models.

The award period is from January 9, 2025 to December 31, 2029, with the goal of developing an improved immunochemotherapy for the treatment of metastatic colorectal cancer.

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