This $398,728 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) supports the development of a novel homologous recombination (HR) inhibitor, CP-8, to sensitize triple-negative breast cancer (TNBC) cells to DNA-damaging agents. The project aims to examine the synergy of CP-8 with various DNA-damaging therapies, including PARP inhibitors and ionizing radiation, in TNBC cell lines, patient-derived xenograft models, and in vivo mouse models. It will assess the drug's target engagement with the recombinase RAD51 and its impact on DNA double-strand breaks. Additionally, the project will conduct IND-enabling pharmacology studies to prepare CP-8 for a future Phase 2 clinical evaluation. This research seeks to provide a safe, reversible approach to resensitize TNBC, including PARP inhibitor-resistant tumors, to DNA-damaging treatments and potentially reduce toxic side effects for patients.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $398.7k | 9/20/23 |