Project Grant R01CA288851

Award Date 1/10/25
Completion Date 12/31/29
Dollars Obligated $620K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This federal Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) totaling $619,764 aims to develop new combination immunotherapy strategies to enhance the anti-tumor efficacy against triple-negative breast cancer (TNBC). The award will fund research to:

  1. Increase tumor-selective accumulation of a platelet-mediated immune checkpoint inhibitor delivery system (P-aPDL1) by triggering local thrombus formation at the TNBC site using a truncated tissue factor-RGD (TTF-RGD) treatment. This will be evaluated in 4T1 TNBC primary and metastatic tumor models.

  2. Modulate the immunosuppressive TNBC tumor microenvironment by depleting tumor-associated macrophages (TAMs) using intratumoral injection of TAM-depleting nanoparticles (PLX-NP). This will be combined with the P-aPDL1 therapy for enhanced anti-tumor efficacy.

  3. Test the combination treatment strategies from the first two aims on a validated patient-derived xenograft (PDX) TNBC humanized mouse model to provide insights for advancing immunotherapies against non-immunogenic tumors.

The grant period runs from January 10, 2025 to December 31, 2029, and the work will be performed by researchers at the University of Wisconsin-Madison.

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