Project Grant R41AR086049
- This Project Grant award of $279,750 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to enhance the efficiency of generating human vasculature in a pig. The goal is to produce human-porcine chimeras that can serve as an unlimited source of organs, such as hearts, for xenotransplantation. The award recipient, Northstar Genomics, LLC, will compare their proven approach using somatic cell nuclear transfer (SCNT) technology with a new method...
- This $234,750 Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) aims to develop foundational tools and resources for non-invasively detecting and tracking implanted cells and tissues in large animal models like pigs. The award has two specific aims: Generate and characterize PET-reporter cells by using CRISPR/Cas technology to create stable transgenic PET reporter cells. These cells will be validated both in vitro and in...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $746,895 to the Regents of the University of Minnesota to establish a non-human primate platform in genetically modified pigs. The goal is to engineer a humanized heart in a gene-edited pig that could serve as an alternative organ source for cardiac transplantation. The key products and services to be delivered...
- This $687,427 Project Grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Federal Grant Program 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of macrophages in guiding digit regeneration. The project leverages a comparative mouse model of bone regeneration and scar formation to study a unique population of macrophages that associates with growing bone and expresses growth factors...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is funding research on the role of HOX-expressing interstitial cells in muscle growth, homeostasis, and regeneration. The $557,357 award, effective from March 14, 2025 through February 28, 2030, will support a University of Wisconsin-Madison research project investigating the ability of a...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training provides $311,168 to Accelerated Muscle Biotechnologies Consultants, L.L.C. to develop infrastructure and capabilities for myocardial and skeletal muscle imaging using synchrotron radiation at the Brookhaven National Labs facility. The key objectives are to: 1) acquire muscle small-angle X-ray scattering (MYSAXS) data comparable to current...
- This $314,000 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training program (CFDA 93.859). The grant was awarded to Cellfe, Inc. to optimize their CellFE microfluidic transfection platform for accelerated, scalable same-day sequential gene editing of T cells for allogeneic cell therapies. The project aims to enhance the speed, precision, and scalability of CRISPR-based gene...
- This Project Grant awarded by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $844,954 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders." The project leverages advanced DNA synthesis and editing capabilities to create genetically engineered mouse models (GREAT-GEMMs) that accurately represent specific human disease phenotypes. These...
- This Project Grant award, valued at $271,664, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The project aims to develop magnetic microgels that can sequentially deliver bone morphogenetic proteins (BMP2 and BMP9) to spatiotemporally control bone and joint formation in a murine digit amputation model. The goal is to create a...
- This federal Project Grant award, with a total funding of $522,764, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant aims to develop a platform technology based on the PiggyBac (PB) transposase, which facilitates precise DNA insertion into specific genomic sequences with minimal off-target effects. This novel gene integration approach is intended to address the limitations of current...
This $286,414 Project Grant awarded on September 10, 2025 by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA 93.351 aims to significantly enhance the efficiency of generating human skeletal muscle in pigs. The primary objective is to develop novel regenerative therapies by producing human skeletal muscle in pigs for reconstructive and transplantation-based surgeries. The grant recipient, Northstar Genomics, LLC, will leverage recent advancements in CRISPR-based zygote gene editing to improve upon their previous somatic cell nuclear transfer (SCNT) and blastocyst complementation platform for this purpose. The work will be conducted at the awardee's research facilities in St. Paul, Minnesota.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $286.4k | 9/10/25 |