Project Grant R41AI145611

The University of Missouri System was awarded a $650,000 Project Grant under the U.S. Department of Agriculture's (USDA) Agriculture and Food Research Initiative (AFRI) program. The grant, awarded on January 1, 2025, supports research to develop a novel vaccine against Bovine Tuberculosis (BTB) caused by Mycobacterium tuberculosis variant bovis (MBO). The research involves genetically engineering the soil bacterium Bacillus subtilis to express immunogenic proteins from the Mycobacterium...

The University of Missouri System, under a $650,000 project grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program, is developing safe and effective live attenuated swine influenza vaccines using Newcastle disease virus (NDV) as the vector. The project aims to address the challenges with current swine influenza vaccines, which often fail to provide cross-protection against diverse virus strains. The key products and...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a novel vaccine candidate against multi-drug resistant Acinetobacter baumannii (MDR-AB). The $288,360 grant, awarded on Dec 23, 2024, will fund research by Biological Mimetics, Inc. to (1) identify key immunogenic components of MDR-AB, (2) develop a prototype vaccine formulation, and (3) conduct preliminary in...

The Department of Agriculture's National Institute of Food and Agriculture awarded Kansas State University $650,000 under the Agriculture and Food Research Initiative competitive grants program to develop improved vaccines for bovine respiratory disease complex. With funding through May 2026, the university aims to generate new knowledge needed to design vaccines capable of protecting calves against multiple strains of Bovine parainfluenza virus 3 and Bovine viral diarrhea virus. Researchers...

This federal Project Grant award of $207,262 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is focused on developing an mRNA vaccine against Bourbon virus, an emerging tick-borne virus that can infect and cause disease in humans. The primary objective is to evaluate the efficacy of the mRNA vaccine in a mouse model and determine its mechanism of action. A secondary objective is to test different viral antigens and...

The Department of Agriculture's National Institute of Food and Agriculture awarded $530,000 under the Agriculture and Food Research Initiative competitive grants program to develop a trivalent vaccine that protects against Marek's disease, Newcastle disease, and infectious laryngotracheitis in poultry. With a completion date of April 30, 2026, this Project Grant will fund research at the Agricultural Research Service's Southeast Area location in Stoneville, MS to design a single vaccine using...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $161,616 to the University of Vermont & State Agricultural College for a research project titled "Understanding the Development of Mucosal Immunity to Poliovirus: Adjuvants and Modulation of the Enteric Microbiota". The goal of this 3-year research project is to characterize human immune responses...

The University of Delaware will conduct research on exosomes and their role in Marek's disease virus vaccination under a $650,000 US Department of Agriculture National Institute of Food and Agriculture Agriculture and Food Research Initiative award. The objectives are to identify how exosomes from vaccinated chickens stimulate immune cells and determine if exosomes alone or in combination with vaccines can enhance protection against Marek's disease virus challenge. The researchers will also...

The U.S. Department of Agriculture (USDA) awarded a $300,000 grant under the Agriculture and Food Research Initiative (AFRI) program to Oklahoma State University (OSU) to develop a novel single-cycle vaccine against bovine respiratory syncytial virus (BRSV). The project aims to pioneer the development of two single-cycle BRSV vaccine prototypes: an 'MNull' vaccine that lacks the essential matrix protein, and a 'PRef' vaccine with a modified fusion protein. OSU will evaluate the immunogenicity...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,162,224 to the University of Pittsburgh to optimize an oral BCG (Bacille Calmette-Guérin) vaccine regimen and evaluate its efficacy against tuberculosis (TB) infection. The research aims to 1) optimize the oral BCG vaccine, 2) compare the protective efficacy of oral BCG to the current standard of intradermal and...