Project Grant 20246701544184

Award Date 1/1/25
Completion Date 12/31/28
Dollars Obligated $650K
Federal Grant Program
10.310
Assistance Type
Project Grant
Place of Performance
Columbia, MO 65211, USA
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The project aims to engineer the soil bacterium Bacillus subtilis to express and display conserved immunogenic peptides/proteins from the M. tuberculosis complex on its spores. These recombinant spores will be tested for their ability to elicit anti-M. bovis cellular and humoral immune responses, as well as in-vivo bacterial killing efficacy, through an oral vaccination-challenge study design.

A sub-award of this grant to Texas Tech University Health Sciences Center at El Paso will provide expertise in generating and validating the recombinant B. subtilis spore system, as well as training on the essential molecular microbial techniques.

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